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教員紹介

所属 薬学部 薬学科 准教授
氏名 大西 敦
最終学歴 北海道大学大学院地球環境科学研究科生態環境科学専攻博士課程 修了
現在所属している学会 日本動物学会、日本農芸化学会
学士・修士・博士 学士(教育学)、修士(地球環境科学)、博士(地球環境科学)
所有資格
研究の分野 基礎生物学、生物科学
主な研究項目 アミノペプチダーゼの基質認識機構に関する研究
主な研究業績 1.Analysis of cDNA clones coding for growth-blacking peptide:an insect biogenic peptide. /In Molecular Mechanisms of Insect Metamorphosis and Diapause (Eds.Suzuki,A.,Kataoka,H.,& Matsumoto,S.),Industrial Publishong & Consulting Inc.,Tokyo.pp.55-63/共著/1995.04
2.昆虫の配偶行動と性フェロモン産生 /蛋白質核酸酵素増刊ケミカルバイオロジー 共立出版 Vol.52 No.13 1679-1684/共著/2007.04
3.第三章-昆虫は化学の力で恋をする /入門ケミカルバイオロジーオーム社 pp.47-63/共著/2008.04
1.Molecular cloning and characterization of cDNA for insect biogenic peptide,growth-blocking peptide.(査読付) /FEBS Lett.376,185-189/共著/1995.04
2.Growth-blocking peptide titer during larval development of parasitized and cold-stressed armyworm.(査読付) /Insect Biochem.Mol.Biol.25,1121-1127/共著/1995.04
4.Cell growth activity of growth-blocking peptide.(査読付) /Biochem.Biophys.Res.Commun.250,194-199/共著/1998.04
3.Mechanism of parastism-induced elevation of hemolymph growth-blocking peptide levels in host insect larvae (Pseudaletia separata).(査読付) /J.Insect Physiol.44,859-866/共著/1998.04
5.Solution structure of insect growth factor, growth-blocking peptide.(査読付) /J.Biol.Chem.274,1887-1890/共著/1999.04
6.Distribution of growth-blocking peptide in the insect central nervous tissue.(査読付) /Cell Tissue Res.300,459-464/共著/2000.04
8.Characterization of receptors of insect cytokine,growth-blocking peptide,in human keratinocyte and insect Sf9 cells.(査読付) /J.Biol.Chem.276,37974-37979/共著/2001.04
7.Structure and activity of the insect cytokine growth-blocking peptide:Essential regions for mitogenic and hemocyte stimulating activities are separate.(査読付) /J.Biol.Chem.276,31813-31818/共著/2001.04
11.Cellular events and molecular mechanisms underlying sex pheromone production in female moths:Analysis in the silkworm,Bombyx mori,as a model. /In Proceedingrs of the 21st Conference of Europian Comparative Endocrinologists (Eds.Keller,R.,Dicksen,H.,Sedlmeier,D.,& Vaudry,H.),Monduzzi Editore,Bologna,p.451-455/共著/2002.04
9.Expression and purification of a amall cytokine growth-blocking peptide from armyworm Psudaletia separata by an optimized fermentation method using the methylotrophic yeast Pichia pastoris.(査読付) /Protein Expr.Purif.25,416-425/共著/2002.04
10.cDNA cloning of calcineurin heterosubunits from the pheromone gland of the silkmoth,Bombyx mori.(査読付) /Insect Biochem.Mol.Biol.32,477-486/共著/2002.04
12.Cloning and characterization of the pheromone biosynthesis activating neuropeptide receptor from the Silkmoth,Bombyx mori:Significance of the carboxyl terminus in receptor internalization.(査読付) /J.Biol.Chem.279,51500-51507/共著/2004.04
15.Isolation and characterization of a humoral factor that stimulates transcription of the acyl-CoA binding protein in the pheromone gland of the silkmoth Bombyx mori.(査読付) /J.Biol.Chem.280,4111-4116/共著/2005.04
14.Further studies of lipid droplets in the bombykol-producing pheromone gland of Bombyx mori.(査読付) /Ann.NY Acad.Sci.1040,310-314/共著/2005.04
13.Regulatory mechanisms underlying pheromone biosynthesis activationg neuropeptide(PBAN)-internalization of the Bombyx mori PBAN receptor.(査読付) /Biochem.Biophys.Res.Commun.334,69-78/共著/2005.04
16.Targeted disruption of genes in the Bombyx mori sex pheromone biosynthetic pathway.(査読付) /Proc.Natl.Acad.Sci.U.S.A. 103,4398-4403/共著/2006.04
20.Synthesis and biological activities of analogs of D-glucosyl-L-tyrosine,a humoral factor that stimulates transcription of the acyl-CoA binding protein in the pheromone gland of the Silkmoth,Bombyx mori.(査読付) /Bioorg.Med.Chem.15,97-103/共著/2007.04
19.Molecular mechanisms underlying sex pheromine production in the silkmoth,Bombyx mori:characterization of the molecular components involved in bombykol biosynthesis.(査読付) /J.Insect Physiol.53,752-759/共著/2007.04
17.Determination of the pheromone producing region that has epoxidation activity in the abdominal tip of the Japanese giant looper,Ascotis selenaria cretacea (Lepidoptera:Geometridae).(査読付) /J.Insect Physiol.53,312-8/共著/2007.04
18.Identidication of a unique pheromonotropic neuropeptide including double FXPRL motifs from a geometrid species,Ascotis selenaria cretacea,which produces an epoxyalkenyl sex pheromone.(査読付) /Insect Biochem.Mol.Biol.37,330-337/共著/2007.04
21.Functional characterization of the Bombyx mori fatty acid transport protein (BmFATP) within the silkmoth pheromone gland.(査読付) /J.Biol.Chem.284,5128-5136/共著/2009.02
22.Molecular mechanisms underlying PBAN signaling in the silkmoth,Bombyx mori.(査読付) /Ann.NY Acard.Sci.1163 464-468/共著/2009.04
23.Novel adaptor protein is essential for insect cytokine signaling in hemocytes.(査読付) /Proc.Natl.Acad.Sci.U.S.A. 107 15862-15867/共著/2010.09
24.Unraveling the pheromone biosynthesis activating neuropeptide (PBAN) signal transduction cascade that regulates sex pheromone production in moths.(査読付) /Vitam.Horm.83 425-445/共著/2010.10
25.RNA interference in Lepidoptera:an overview of successful and unsuccessful studies and implications for experimental design.(査読付) /J.Insect Physiol.,57 231-245/共著/2011.02
26.昆虫における性フェロモン生合成のホルモン制御:神経ホルモンPBANによるガ類性フェロモン産生の分子機構の全貌解明を目指して /比較内分泌学 Vol.37 No.142 139-143/共著/2011.04
27.Studies of sex pheromone production under neuroendocrin control by analytical and morphological means in the oriental armyworm,Pseudaletia seoarata,Walker (Lepidoptera Noctuidae).(査読付) /Gen.Comp.Endocrinol.172 62-76/共著/2011.05
28.Hormone signaling linked to silkmoth sex pheromone biosynthesis involves Ca2+/calmodulin-dependent protein kinase Ⅱ(CaMKⅡ)-mediated phosphorylation of the insect PAT family protein Bombyx mori lipid storage protein-1 (BmLSD1).(査読付) /J.Biol.Chem.286 24101-24112/共著/2011.07
29.Screening for the genes involved in bombykol biosynthesis: Identification and functional characterization of Bombyx mori acyl carrier protein (BmACP).(査読付) /Front.Endocrin.2 92/共著/2011.12
30.Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress.(査読付) /Sci.Rep.2 210/共著/2012.01
31.Characteristics common to a cytokine family spanning five orders of insects.(査読付) /Insect Biochem.Mol.Biol. 42 446-454/共著/2012.06
32. Role of glutamine-169 in the substrate recognition of human aminopeptidase B.(査読付) /Biochim Biophys Acta.1840 1872-1881/共著/2014.06
33. Involvement of phenylalanine-297 in the construction of the substrate pocket of human aminopeptidase B. /Biochemistry 54, 6062–6070/共著/2015.10
主な担当授業科目名 遺伝子の構造・機能 生化学 薬学基礎実習

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