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教員紹介

所属 健康医療スポーツ学部 理学療法学科 教授
氏名 佐々木 博之
最終学歴 新潟大学大学院修士課程 修了
現在所属している学会 日本解剖学会、日本臨床分子形態学会、医学生物学電子顕微鏡技術学会、The American Society for Cell Biology
学士・修士・博士 医学博士
所有資格
研究の分野 基礎医学、生物科学
主な研究項目 解剖学、形態学、細胞生物学
主な研究業績 生殖機能の組織学 /理工学社/共著/
電子顕微鏡でみるミクロの世界(生物編) /学際企画/単著/1995.11
Methods in Molecular Medicine. /Vol.86,Renal Disease.Techniques and Protocols,2003,pp.155-66,Humana Press inc.,Totowa,NJ./単著/2003.01
Expression of claudin-5 in dermal vascular endothelia. /Exp.Dermatol.2003 12:289-95./共著/2003.01
Size-selective loosening of the blood-barrier in claudin-5-deficient mice. /J.Cell Biol.2003 161:653-60./共著/2003.02
Claudins in Caenorhabditis slsgans:Their distribution and barrier function in the epithelium. /Curr.Biol.2003 13:1042-6./共著/2003.03
Dynamic behavior of paired claudin strands within apposing plasma membranes. /Proc.Natl.Acad.Sci.USA.2003 100:3971-6./共著/2003.04
Cross-bridge number,position,and angle in target zones of cryofixed isometrically active insect flight muscle. /Biophys.J. 2004 86:3009-19./共著/2004.01
Actin filaments play an essential role for transport of nascent HIV-1 proteins in host cells. /Biochem.Biophys.Rec.Commun. 2004 316:588-93./共著/2004.02
Electron tomography of fast frozen,stretched rigor fibers reveals elastic distortions in the myosin crossbridges. /J.Struct.Biol.2004 147:268-82./共著/2004.03
JACOP,A novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin. /J.Biol.Chem.2004 279:46014-22/共著/2004.04
Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia. /J.Cell Biol.2004 166:559-70./共著/2004.05
Establishment and characterization of cultured eqithelial cells lacking expression of ZO-1. /J.Biol.Chem.2004 279:44785-94./共著/2004.06
Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential. /J.Cell Sci.2004 117(Pt 21):5087-96./共著/2004.08
CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. /J.Cell Biol.2005 168:141-53./共著/2005.02
Tight junctions in Schwann cells of peripheral myelinated axons:a lesson from claudin-19-deficient mice. /J.Cell Biol.2005 169:527-38./共著/2005.03
α1-Adrenoceptor stimulation potentiates L-type Ca2+ current through Ca2+/calmodulin-dependent PK II (CaMKII) activation in rat ventricular myocytes. /Proc.Natl.Acad.Sci.USA.2005 102:9400-5./共著/2005.04
Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. /J.Cell Biol.2005 171:939-45./共著/2005.05
Mannalian CLASPs are required for mitotic spimdle organization and kinetochore alignment. /Genes Cells 2006 11:845-57./共著/2006.02
ZO-1 and/or ZO-2 determine whether and where claudins are polymerized into tight junction strands. /Cell 2006 126:741-54./共著/2006.03
Conversion of a monodispersed globular probular protein into an amyloid-like filament by appending an artificial peptide at the N-terminal. /Protein Eng.Des.Sel.2007 20:109-16./共著/2007.01
Adenomatous polyposis coli (APC) protein regulates epithelial cell migration and morphogenesis via PDZ domain-based interactions with plasma membranes. /Genes Cells 2007 12:219-33.//2007.02
Megaintestine in claudin-15-deficint mice. /Gastroenterology.2008 134(2):523-34./共著/2008.02
Relationship between expression of tight junction-related molecules and perturbed epidermal barrier function in UVB-irradiated hailess mice. /Arch.Dermatol.Res.2008 300:61-8./共著/2008.03
Effect of RNA interference of tight junction-related molecules on intercellular barrier function in cultured human keratinocytes. /Arch.Dermatol.Res.2008 300:517-524/共著/2008.04
Interaction of α-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. /Circ Res.2008 102(11):1378-88/共著/2008.05
Loss of occludin affects tricellular localization of tricellulin. /Mol.Biol.Cell.2008 19:4687-4693/共著/2008.06
Regulation of tight junction permeability by sodium caprate in human kerationocytes and reconstructed epidermis. /Biochem.Biophys.Res.Commun.2009 381:171-175/共著/2009.01
Epidermal tight junction:the master skin barrier regulator. /IFSCC Magazine 2009 12:2-6/共著/2009.02
Latrunculin A has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice. /Anticancer Res.2009 29:2091-2098/共著/2009.03
Protein kinase A-dependent phosphorylation of ryanodine receptors increases Ca2+ leak in mouse heart. /Biochem.Biophys.Res.Commun.2009 390(1):87-92./共著/2009.04
External antigen uptake by Langerhans cells with recognization of epidermal tight junction barriers. /J.Exp.Med.2009 206(13):2937-46./共著/2009.05
Tight junction-associated MARVEL proteins Marve1D3,tricellulin,and occludin have distinct but overlapping functions. /Mol.Biol.Cell 2010 21:1200-1213./共著/2010.02
Claudin-2-deficint mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. /Proc.Natl.Acad.Sci.USA.2010 107(17):8011-6./共著/2010.03
Electron tomography of cryofixed,isometrically contracting insect flight muscle reveals novel actin-myosin interactions. /PLoS One.2010 Sep.5(9):e12643./共著/2010.09
Tight junction regulates epidermal calcium ion gradint and differentiation. /Biochem.Biophys.Res.Commun.2011.406(4):506-511./共著/2011.01
Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining. /Front.Cellular Neurosci.2012 6:1-14/共著/2012.06
Structural changes in isometrically contracting insect flight muscle trapped following a mechanical perturbation. /PLoS One.2012 7(6):e39422./共著/2012.06
TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. /Elife.2014 1;3:e01566. doi: 10.7554/eLife.01566./共著/2013.03
Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells. /Biology Open 3, 759-66, doi:10.1242/bio. 20147799./共著/2014.07
Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study. /Front.Cellular Neurosci.20 2015 9:1-11/共著/2015.03
(総説)高圧凍結法とフリーズフラクチャーレプリカ法 /電子顕微鏡 2001 36:102-4./共著/2002.01
(総説)クローディンによるタイトジャンクションの自動開閉 /Bio Medical Quick Reviw Net 2003 19:1-5./単著/2003.03
(総説)A look at tricellulin,a recently discovered tight junction protein. /Eur.J.Cell Biol.2011 90:787-796./共著/2011.01
(総説)Freeze-fracture electronmicroscopy for cell-cell junctions. /J.Elecr.Microsc.Techol.Med.Biol.2012 26:1-7./共著/2012.01
密着結合はいかに密着しているか? /帝京平成大学紀要 第26巻第1号:125-131/単著/2015.03
主な担当授業科目名 人体の構造(講義と実習)、疾病救急1、特別総合演習、卒業研究

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