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教員紹介

所属 薬学部 薬学科 教授
氏名 清水 俊一
最終学歴 昭和大学大学院薬学研究科博士前期課程
現在所属している学会 日本薬理学会、日本薬学会、日本生化学会、日本NO学会、TRP研究会(生理学研究所)
学士・修士・博士 博士(薬学)
所有資格 薬剤師免許
研究の分野 生物系薬学、薬理学一般
主な研究項目 炎症性疾患におけるTRPチャネルの役割,TRPチャネル阻害剤の探索とその応用,心機能調節におけるTRPチャネルの役割,固形がんの成長におけるTRPチャネルの関与
主な研究業績 イラストでみる疾病の成り立ちと薬物療法 /医学評論社/共著/2013.09
TRPs as Chemosensors (ROS, RNS, RCS, Gasotransmitters). /Mammalian Transient Receptor Potential (TRP) Cation Channels, Handbook of Experimental Pharmacology 223, pp. 767-794, Springer International Publishing Switzerland/共著/2014.07
構造式手帳 /京都廣川書店/共著/2016.03
Targeting TRPM2 in ROS-coupled diseases. / Pharmaceuticals, doi:10.3390/ph9030057/共著/2016.09
Significance of TRP channels in oxidative stress. /Eur J Pharmacol., 793, 109-111/共著/2016.11
Identification of regulatory sites in the biosynthesis of ubiquinone in the perfused rat heart.(査読付き) /Arch. Biochem. Biophys., 269, 86-92, 1989/共著/1989.01
Possible existence of an intermediate pool of ubiquinone in rat heart mitochondria.(査読付き) /Int. J. Biochem., 22, 89-91, 1990/共著/1990.01
Inhibition of ubiquinone synthesis in isolated rat heart under an ischemic condition.(査読付き) /Int. J. Biochem., 22, 477-480, 1990/共著/1990.05
Possible involvement of 3-hydroxymethylglutaryl-CoA reductase in determining the side-chain length of ubiquinone in rat heart.(査読付き) /Arch. Biochem. Biophys., 284, 35-39, 1991/共著/1991.02
Reduction by NG-nitro-L-arginine of H2O2-induced endothelial cell injury.(査読付き) /Br. J. Pharmacol., 113, 564-568, 1994/共著/1994.10
The effects of hypoxia on pHi in porcine coronary artery endothelium and smooth muscle. A novel method for measurement in endothelial cell in situ.(査読付き) /Circ. Res., 80, 21-27, 1997/共著/1997.01
Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin content.(査読付き) /Life Sci., 61, 739-747, 1997/共著/1997.02
The endothelium-dependent, substance P relaxation of porcine coronary arteries resistant to nitric oxide synthesis inhibition is partially mediated by 4-aminopyridine-sensitive voltage-dependent K+ channels.(査読付き) /Endothelium, 5, 287-295, 1997/共著/1997.04
Possible involvement of nitric oxide synthase in oxidative stress-induced endothelial cell injury.(査読付き) /Pharmacol. Toxicol., 80, 191-196, 1997/共著/1997.04
Cold storage induces an endothelium-independent relaxation to hypoxia/reoxygenation in porcine coronary arteries.(査読付き) /J. Vasc. Res., 34, 399-407, 1997//1997.09
Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury.(査読付き) /Pharmacol. Toxicol., 82, 280-286, 1998/共著/1998.01
Stimulation of nitric oxide synthase during oxidative endothelial cell injury.(査読付き) /Biochem. Pharmacol., 55, 77-83, 1998/共著/1998.01
Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells.(査読付き) /Am. J. Physiol., 274, C472-C480, 1998/共著/1998.02
Protective effects of tetrahydrobiopterin against nitric oxide induced endothelial cell death.(査読付き) /Life Sci., 63, 1585-1592, 1998//1998.02
Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain.(査読付き) /J. Biol. Chem., 273, 10279-10287, 1998/共著/1998.04
Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells.(査読付き) /Life Sci., 64, 249-258, 1999/共著/1999.01
Stimulation of in vitro angiogenesis by tetrahydrobiopterin in bovine aortic endothelial cells. /Jpn. J. Pharmacol., 80, 177-180, 1999/共著/1999.01
Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta. / Life Sci., 65, 2769-2779, 1999/共著/1999.02
SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: protective effect of sepiapterin. /J. Cardiovasc. Pharmacol., 33, 295-300, 1999/共著/1999.02
[Ca2+]i homeostasis and cyclic nucleotide relaxation in aorta of phospholamban-deficient mice. /Am. J. Physiol., 277, H963-H970, 1999/共著/1999.09
Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. /J. Biol. Chem., 274, 27359-27370, 1999/共著/1999.09
Hypoxia and alkalinization inhibit endothelium-derived nitric oxide but not endothelium-derived hyperpolarizing factor responses in porcine coronary artery. /J. Pharmacol. Exp. Ther., 291, 335-344, 1999/共著/1999.10
Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats. /Dig. Dis. Sci., 45, 93-98, 2000/共著/2000.01
Role of voltage-dependent and Ca2+-activated K+ channels on the regulation of isometric force in porcine coronary artery. /J. Vasc. Res., 37, 16-25, 2000/共著/2000.01
Effects of hypoxia on isometric force, intracellular Ca2+, pH, and energetics in porcine coronary artery. / Circ. Res., 86, 862-870, 2000//2000.04
A novel effect of polymorphonuclear leukocytes in the facilitation of angiogenesis. /Life Sci., 66, 2113-2121, 2000/共著/2000.05
Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase. /Int. J. Biochem. Cell Biol., 33, 65-73, 2001/共著/2001.01
The transient receptor potential protein homologue TRP6 is the essential component of vascular 1-adrenoceptor-activated Ca2+-permeable cation channel. /Circ. Res., 88, 325-332, 2001/共著/2001.02
Hypoxic vasodilation in porcine coronary artery is preferentially inhibited by organ culture. /Am. J. Physiol., 281, C24-C32, 2001/共著/2001.07
Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells. /Jpn. J. Pharmacol., 87, 51-60, 2001//2001.09
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. /Mol. Cell, 9, 163-173, 2002/共著/2002.01
Ets-1 upregulates matrix metalloproteinase-1 expression through extracellular matrix adhesion in vascular endothelial cells. /Biochem. Biophys. Res. Commun., 291, 130-138, 2002/共著/2002.02
Differential roles of ICAM-1 and E-selectin in polymorphonuclear leukocyte-induced angiogenesis. /Am. J. Physiol., 282, C917-C925, 2002/共著/2002.04
Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells. /Int. J. Biochem. Cell Biol., 34, 1134-1141, 2002//2002.09
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells. /Free Radic. Biol. Med., 34, 1343-1352, 2003/共著/2003.03
Stimulation of in vitro angiogenesis by nitric oxide through the induction of transcription factor ETS-1. /Int. J. Biochem. Cell Biol., 36, 114-122, 2004//2004.01
Reduction of GTP cyclohydrolase I feedback regulating protein expression by hydrogen peroxide in vascular endothelial cells. /J. Pharmacol. Sci., 97, 299-302, 2005//2005.02
Possible involvement of hydroxyl radical on the stimulation of tetrahydrobiopterin synthesis by hydrogen peroxide and peroxynitrite in vascular endothelial cells. /Int. J. Biochem. Cell Biol., 37, 864-875, 2005/共著/2005.04
Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. /J. Physiol., 570, 219-235, 2006/共著/2006.01
Intracellular-produced hydroxyl radical mediates H2O2-induced Ca2+ influx and cell death in rat β-cell line RIN-5F. /Cell Calcium, 39, 487-494, 2006/共著/2006.01
Extracellular-added ADP-ribose increases intracellular free Ca2+ concentration through Ca2+ release from stores, but not through TRPM2-mediated Ca2+ entry, in rat beta-cell line RIN-5F. /J. Pharmacol. Sci., 101, 174-178, 2006/共著/2006.01
Reduction of myocardial infarct size by tetrahydrobiopterin: Possible involvement of mitochondrial KATP channels activation through nitric oxide production. /J. Cardiovasc. Pharmacol., 47, 243-249, 2006/共著/2006.02
Nitric oxide activates TRP channels by cysteine S-nitrosylation. /Nat. Chem. Biol., 2, 596-607, 2006/共著/2006.12
Facilitation of H2O2-induced A172 human glioblastoma cell death by insertion of oxidative stress-sensitive TRPM2 channels. /Anticancer Res., 27, 3987-3992, 2007/共著/2007.11
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells. /Int. J. Biochem. & Cell Biol., 40, 755-765, 2008/共著/2008.04
TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. /Nat. Med., 14, 738-747, 2008/共著/2008.07
Inhibitory effect of lomerizine , a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery. /J. Pharmacol. Sci., 111, 221-225, 2009/共著/2009.10
An important role of increase in tetrahydrobiopterin via H2O2/Jak2 signaling pathway in late phase of ischaemic preconditioning. /Exp. Physiol., 95, 609-621, 2010/共著/2010.03
Impaired Ca2+ regulation of CD4+CD25+ regulatory Y cells from pediatric asthma. /Int. Arch. Allergy Immunol.,156, 148-158, 2011/共著/2011.02
AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells. /Biochem. J. 437, 345-355, 2011/共著/2011.07
Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity. /Mol. Cell. Biochem. 358, 1-11, 2011/共著/2011.12
Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells. /Biol. Pharm. Bull., 35, 346-354, 2012/共著/2012.03
MAOA, MTHFR, and TNF-genes polymorphisms and personality traits in the pathogenesis of migraine. /Mol. Cell. Biochem., 363, 357-366, 2012/共著/2012.04
Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury. /Cardiovasc. Res., 97, 271-281, 2013/共著/2013.02
Decreased cardiac mitochondrial tetrahydrobiopterin in a rat model of pressure overload. /Int. J. Mol. Med., 31, 589-596, 2013/共著/2013.03
Potentiated macrophage activation by acid sensing under low adiponectin levels. /Mol. Immunol., 57, 141-150, 2014/共著/2014.02
Involvement of TRPM2 and L-type Ca2+ channels in Ca2+ entry and cell death induced by hydrogen peroxide in rat -cell line RIN-5F. /J Toxicol Sci, 39, 199-209, 2014/共著/2014.04
Elevated receptor for activated C kinase 1 expression is involved in intracellular Ca2+ influx and potentially associated with compromised regulatory T cell function in patients with asthma. /Clin Exp Allergy, 44, 1154-1169, 2014/共著/2014.09
Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry. /Eur J Pharmacol, 742, 22-30, 2014/共著/2014.11
TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation. /Free Radic Biol & Med., 90, 101–113/共著/2015.11
Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activation. /Eur J Pharmacol., 786, 19-28/共著/2016.05
Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe2+ in human monocytic U937 cells. /Int J Biochem & Cell Biol., 68, 119-127/共著/2016.11
Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses. /J Pharmacol Sci., 134, 68-74/共著/2017.05
Role of tetrahydrobiopterin in the function of nitric oxide synthase, and its cytoprotective effect (Review). /Int. J. Mol. Med., 2, 533-540, 1998./共著/1998.11
Receptor-activated Ca2+ influx: capacitative Ca2+ entry and TRP proteins. /Nippon Yakurigaku Zasshi, 114, 149-160, 1999/共著/1999.09
Protective effect of tetrahydrobiopterin against reactive oxygen species- and nitric oxide-induced vascular endothelial cell injury. /Pteridines, 13, 32-37, 2002/単著/2002.01
Ca2+ channel alpha1B subunit (CaV 2.2) knockout mouse reveals a predominant role of N-type channels in the sympathetic regulation of the circulatory system. /Trends Cardiovasc. Med., 12, 270-274/共著/2002.06
TRPM2 チャネルによる活性酸素シグナルの増幅と慢性炎症の関連 /日本薬理学雑誌 134, 122-126, 2009/共著/2009.01
酸化ストレス作動性TRPチャネルと消化管炎症 /Journal of Gastrointestinal Research 19, 4-12, 2011/共著/2011.01
活性酸素感受性Ca2+透過性チャネルTRPM2の活性化による炎症反応の増幅 /生化学 83, 1100-1103, 2011/共著/2011.01
主な担当授業科目名 薬理学Ⅰ、薬理学Ⅱ、薬学総括講義Ⅲ、生物系実習(薬理学)

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