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教員紹介

所属 薬学部 薬学科 講師
氏名 戸田 雄大
最終学歴 星薬科大学大学院薬学研究科医療薬科学専攻 博士課程後期 修了
現在所属している学会 日本薬学会、日本薬理学会
学士・修士・博士 学士(薬学)、 修士(薬学)、 博士 (薬学)
所有資格 薬剤師免許
研究の分野 医歯薬学 薬理学
主な研究項目 TRPチャネル阻害剤の探索とその応用
主な研究業績 Juzentaihoto reduces post-partial hepatectomy hyperammonemia by stabilizing intestinal microbiota.(査読付き) /J. Trad. Med., 23, 208-215/共著/2006.11
漢方専門外来受診患者における漢方薬服用に関する実態調査(1) 漢方薬と西洋薬の併用.(査読付き) /医療薬学, 33, 353-358/共著/2007.06
Effect of hydrocotarnine on cytochrome P450 and P-glycoprotein. (査読付き) /Drug Metab. Pharmacokinet., 24, 108-113(2009)/共著/2009.02
Intestinal flora induces the expression of Cyp3a in the mouse liver.(査読付き) /Xenobiotica, 39, 323-334/共著/2009.04
抗生物質を投与するとリトコール酸産生菌の減少に伴ってマウスの肝臓におけるCyp3aが減少する。(査読付き) /Yakugaku Zasshi, 129, 601-608/共著/2009.05
Ciprofloxacin suppresses Cyp3a in mouse liver by reducing lithocholic acid-producing intestinal flora.(査読付き) /Drug Metab. Pharmacokinet., 24, 201-208/共著/2009.07
Altered expression of CYP in TSOD mice: a model of type 2 diabetes and obesity.(査読付き) /Xenobiotica, 39, 889-902/共著/2009.12
Differences in the pharmacokinetics of Cyp3a substrates in TSOD and streptzotocin-induced diabetic mice.(査読付き) /Xenobiotica, 40, 282-290/共著/2010.04
The role of renal aquaporin 2 in the alleviation of dehydration associated with diabetic polyuria in KKAy mice.(査読付き) /Life Sci, 87, 475-480/共著/2010.08
Increases in the expression levels of aquaporin-2 and aquaporin-3 in the renal collecting tubules alleviate dehydration associated with polyuria in diabetes mellitus.(査読付き) /Biol., Pharm. Bull, 33, 1965-1970/共著/2010.12
Anti-obesity and anti-diabeticeffects of acacia polyphenol in obese diabetic KKAy mice fed high-fat diet. (査読付き) /Evid. Based Complement. Alternat. Med., (2011) doi: 10.1093/ecam/nep241./共著/2011.04
Inhibition of preadipocyte differentiation and lipid accumulation by Orengedokuto treatment of 3T3-L1 cultures.(査読付き) /Phytother. Res., 26, 91-100/共著/2012.01
Inhibitory effect of polyphenol-rich fraction from the bark of Acacia mearnsii on itching associated with allergic dermatitis.(査読付き) /Evid. Based Complement. Alternat. Med., doi: 10.1155/2012/120389/共著/2012.01
Gypsum fibrosum and its major component CaSO4 increase cutaneous aquaporin-3 expression levels.(査読付き) /Ethnopharmacol., 31, 409-413/共著/2012.01
The concomitant use of an osmotic laxative, magnesium sulphate, and a stimulant laxative, bisacodyl, does not enhance the laxative effect.(査読付き) /Eur. J. Pharm. Sci., 45, 73-78/共著/2012.01
Effect of Conclevan on endurance capacity in mice.(査読付き) /Biol. Pharm. Bull., 35, 231-238/共著/2012.02
Inhibition of aquaporin-3 water channel in the colon induces diarrhea.(査読付き) /Biol. Pharm. Bull., 35, 957-962/共著/2012.06
Consumption of a high-fat diet during pregnancy decreases the activity of cytochrome P450 3a in the livers of offspring.(査読付き) /Eur. J. Pharm. Sci., 47, 108-116/共著/2012.08
(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects.(査読付き) /Bioorg. Med. Chem. Lett., 22, 7602-7604 /共著/2012.12
Consumption of a high-fat diet during pregnancy changes the expression of cytochrome P450 in the livers of infant male mice.(査読付き) /Biol. Pharm. Bull. 36, 649-657/共著/2013.01
Different diets cause alterations in the enteric environment and trigger changes in the expression of hepatic Cytochrome P450 3A, a drug-metabolizing enzyme.(査読付き) /Biol. Pharm. Bull. 36, 624-634/共著/2013.02
Synthesis of am80 (tamibarotene) prodrug candidates, congeners and metabolites.(査読付き) /Chem Pharm Bull. 61, 846-852/共著/2013.08
A novel aromatic carboxylic Acid inactivates luciferase by acylation of an enzymatically active regulatory lysine residue.(査読付き) /PLoS One, 16, e75445/共著/2013.09
Total gastrectomy may result in reduced drug effectiveness due to an increase in the expression of the drug-metabolizing enzyme Cytochrome P450, in the liver.(査読付き) /Eur J Pharm Sci., 51, 180-188/共著/2014.01
Gastrectomy increases the expression of hepatic cytochrome P450 3A by increasing lithocholic acid-producing enteric bacteria in mice.(査読付き) /Biol Pharm Bull., 37, 298-305/共著/2014.11
Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry. (査読付き) /Eur, J, Pharmacol., 742C, 22-30/共著/2014.11
Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe(2+) in human monocytic U937 cells.(査読付き) /Int. J. Biochem. Cell Biol., 16 119-127/共著/2015.11
Serotonergic mechanisms are involved in antidepressant-like effects of bisbenzylisoquinolines liensinine and its analogs isolated from the embryo of Nelumbo nucifera Gaertner seeds in mice.(査読付き) /J. Pharm. Pharmacol., inpress, doi: 10.1111/jphp.12473/共著/2015.12
TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation.(査読付き) /Free Radic. Biol. Med., 90 101-113/共著/2016.01
Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activation.(査読付き) /Eur. J. Pharmacol., 786 19-28/共著/2016.09
Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses.(査読付き) /J. Pharmacol. Sci., 134 68-74/共著/2017.05
主な担当授業科目名 生物系実習Ⅱ、アドバンスセミナーⅠA、薬学総括講義Ⅲ、臨床薬学実習Ⅱ、卒業研究、薬科学総合講義Ⅴ、分子薬理学特論

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