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教員紹介

所属 薬学部 薬学科 教授
氏名 石井 正和
最終学歴
現在所属している学会 日本薬理学会、日本薬学会
学士・修士・博士 博士(薬学)
所有資格 薬剤師免許
研究の分野 薬学、基礎医学、内科系臨床医学
主な研究項目 慢性頭痛の病態解明および治療反応性に関与する因子の探索,抗がん剤の副作用発現機構の解明
主な研究業績 薬剤師 MR コメディカルのための救急医療マニュアル /エルゼビア・ジャパン/共著/
Bradykinin induces generation of reactive oxygen species in bovine aortic endothelial cells. /Res. Commun. Chem. Pathol. Pharmacol./共著/1994.06
Mechanism of nitric oxide production by H2O2 in cultured endothelial cells. /Res. Commun. Mol. Pathol. Pharmacol./共著/1997.03
Possible involvement of nitric oxide synthase in oxidative stress-induced endothelial cell injury. /Pharmacol. Toxicol./共著/1997.04
Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin content. /Life Sci. /共著/1997.07
Changes in nitric oxide synthase activity during exposure to hydrogen peroxide in cultured endothelial cells. /Res. Commun. Mol. Pathol. Pharmacol./共著/1997.09
Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury. /Pharmacol. Toxicol./共著/1998.06
Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death. /Life Sci. /共著/1998.09
Insulin stimulates tetrahydrobiopterin synthesis in mouse brain microvascular endothelial cells. /Pteridines/共著/1999.01
SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: Protective effect of sepiapterin. /J. Cardiovasc. Pharmacol./共著/1999.02
Characterization of the protective effect of tetrahydrobiopterin against S-nitroso-N-acetyl-D,L-penicillamine induced endothelial cell injury. /Pteridines/共著/1999.02
Stimulation of in vitro angiogenesis by tetrahydrobiopterin in bovine aortic endothelial cell. /Jpn. J. Pharmacol. /共著/1999.06
Role of tetrahydrobiopterin in the function of nitric oxide synthase, and its cytoprotective effect (Review). /Int. J. Mol. Med./共著/1999.11
Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats: Protective effect of tetrahydrobiopterin. /Dig. Dis. Sci./共著/2000.01
Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta. / Life Sci./共著/2000.11
Stimulation of tetrahydrobiopterin synthesis by 17ß-estradiol in brain microvascular endothelial cells. /Pteridines /共著/2000.11
Troglitazone stimulates the insulin-induced tetrahydrobiopterin synthesis in vascular endothelial cells. /Pteridines /共著/2000.11
Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase. /Int. J. Biochem. Cell Biol./共著/2001.01
Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells. /Jpn. J. Pharmacol./共著/2001.09
Negative regulation of insulin-induced tetrahydrobiopterin synthesis by protein kinase C in vascular endothelial cells. /Pteridines/共著/2001.09
Dissecting receptor-mediated Ca2+ influx pathways: TRP channels and their native counterparts. /Jpn. J. Pharmacol./共著/2001.12
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. /Mol. Cell/共著/2002.01
Stimulation of tetrahydrobiopterin synthesis by cyclosporin A during lipopolysaccharide treatment in vascular endothelial cells. /Pteridines/共著/2002.02
Ca2+ channel alpha1B subunit (Ca(V) 2.2) knockout mouse reveals a predominant role of N-Type channels in the sympathetic regulation of the circulatory system. /Trends Cardiovasc. Med. /共著/2002.08
Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells. /Int. J. Biochem. Cell Biol. /共著/2002.09
Hydrogen peroxide stimulates the LPS-induced tetrahydrobiopterin synthesis in mouse brain microvascular endothelial cells. /Pteridines/共著/2003.05
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells. /Free Radic. Biol. Med./共著/2003.05
Stimulation of tetrahydrobiopterin synthesis by basic fibroblast growth factor in vascular endothelial cells. /Pteridines/共著/2003.10
Stimulation of tetrahydrobiopterin synthesis by peroxynitrite in vascular endothelial cells. /Pteridines/共著/2003.11
Decrease in tetrahydrobiopterin content promotes L-arginine-induced elevation of cytosolic calcium concentration in insulin-secreting cells. /Pteridines/共著/2003.12
Possible role of BH4 as one of the cell defense system against reactive oxygen species-induced toxicity. /Recent Res. Devel. Life Sci. /共著/2003.12
Reduction of GTP cyclohydrolase I feedback regulating protein expression by hydrogen peroxide in vascular endothelial cells. /J. Pharmacol. Sci. /共著/2005.02
Possible involvement of hydroxyl radical on the stimulation of tetrahydrobiopterin synthesis by hydrogen peroxide and peroxynitrite in vascular endothelial cells. /Int. J. Biochem. Cell Biol./共著/2005.04
Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. /J. Physiol./共著/2006.01
Extracellular-added ADP-ribose increases intracellular free Ca2+ concentration through Ca2+ release from stores, but not through TRPM2-mediated Ca2+ entry, in rat beta-cell line RIN-5F. /J. Pharmacol. Sci. /共著/2006.06
Tetrahydrobiopterin regulates L-tyrosine-induced elevation of cytosolic calcium concentration in insulin-secreting cells. /Pteridines/共著/2006.06
Intracellular-produced hydroxyl radical mediates H2O2-induced Ca2+ influx and cell death in rat beta-cell line RIN-5F. /Cell Calcium/共著/2006.06
Beneficial role of tetrahydrobiopterin on various cardiovascular diseases and regulation of its levels under pathological conditions. /Pteridines/共著/2006.12
Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children. /Pediatr Allergy Immunol./共著/2006.12
Reduction of myocardial infarct size by tetrahydrobiopterin: Possible involvement of mitochondrial KATP channels activation through nitric oxide production. /J. Cardiovasc. Pharmacol. /共著/2007.02
Facillitation of H2O2-induced A172 human glioblastoma cell death by insertion of oxidative stress-sensitive TRPM2 channels. /Anticancer Res./共著/2007.11
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells. /Int. J. Biochem. Cell Biol./共著/2008.01
Insulin secretion in response to L-arginine under decreasing tetrahydrobiopterin content. /Pteridines/共著/2008.12
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. /Proc. Natl. Acad. Sci. USA./共著/2009.03
Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery. /J. Pharmacol. Sci./共著/2009.10
Targeted disruption of the voltage-dependent Ca2+ channel alpha2/ delta-1 subunit. /Am. J. Physiol. Heart Circ. Physiol./共著/2009.10
Association of the A-1438G polymorphism in serotonin 2A receptor in migraine with aura among Japanese patients. /Biol. Pharm. Bull./共著/2010.08
Presynaptic stimulus-release and postsynaptic compensatory changes in mice lacking the N-type calcium channel alpha(1B)-subunit. /Auton. Neurosci./共著/2011.02
Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity. /Mol. Cell. Biochem. /共著/2011.12
Impaired Ca2+ regulation in CD4+CD25+ regulatory T cells from pediatric asthma patients. /Int. Arch. Allergy Immunol./共著/2011.12
MAOA, MTHFR and TNF-beta genes polymorphisms and personality traits in the pathogenesis of migraine. /Mol. Cell. Biochem. /共著/2012.04
Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells. /Biol. Pharm. Bull./共著/2012.04
Negative predictors of clinical response to triptans in patients with migraine. /Neurol. Sci./共著/2012.04
Association of genetic, psychological, and behavioral factors with sleep bruxism in a Japanese population. /J. Sleep Res./共著/2012.06
Association between the G252A tumor necrosis factor-beta gene polymorphism and medication-overuse headache. /J. Clin. Neurol./共著/2012.12
Predictive index for the onset of medication overuse headache in migraine patients. /Neurol. Sci./共著/2013.01
Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischemia/reperfusion injury. /Cardiovasc. Res./共著/2013.02
Decresed cardiac mitochondrial tetrahydrobiopterin in a rat model of pressure overload. /Int. J. Mol. Med./共著/2013.03
Prediction and structural equation model of sertraline treatment response in Japanese patients with major depressive disorder. /Hum. Psychopharmacol. Clin. Exp./共著/2013.11
Characteristics of inconsistent responders to prophylaxis therapy with lomerizine in patients with migraine: a retrospective study in Japan. / J. Neurol. Sci./共著/2013.12
Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches. /Acta Neurol. Taiwan./共著/2013.12
Influence of the Tohoku-Pacific ocean earthquake and its aftershocks on the response to prophylactic therapy with lomerizine in patients with migraine in Tokyo: a retrospective study. /Eur. Neurol./共著/2014.02
Involvement of TRPM2 and L-type Ca2+ channels in Ca2+ entry and cell death induced by hydrogen peroxide in rat β-cell line RIN-5F. /J. Toxicol. Sci./共著/2014.04
MAOA and TNF-beta gene polymorphisms are associated with photophobia but not osmophobia in patients with migraine. /Acta Neurol. Taiwan. /共著/2014.06
Polymorphisms of nitric oxide synthase and GTP cyclohydrolase I genes in Japanese patients with medication overuse headaches. /Neurol. Asia/共著/2014.08
Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry. /Eur. J. Pharmacol. /共著/2014.11
Catechol-O-methyl transferase gene polymorphisms in Japanese patients with medication overuse headache. /JSM Genet. Genomics./共著/2015.01
Lack of association between CGRP-related gene polymorphisms and medication overuse headache in migraine patients. /Integr. Mol. Med./共著/2015.01
A cyclooxygenase 2 gene polymorphism is a risk factor for the complication of medication overuse headaches in patients with migraines. /J. Neurol. Disord./共著/2015.02
Practical prognostic index for survival in patients with unresectable pancreatic cancer treated with gemcitabine or S-1. /Hepato-Gastroenterology/共著/2015.02
Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe2+ in human monocytic U937 cells. /Int. J. Biochem. Cell Biol. /共著/2015.09
Orexin receptor gene polymorphisms in Japanese migraine patients with medication overuse headache. /J. J. Neur. Neurosci./共著/2015.10
Antioxidant enzyme gene polymorphisms in Japanese migraine patients with medication overuse headache. /Int. J. Neurol. Res. /共著/2015.12
Chemotherapy-induced neutropenia as a prognostic factor in patients with unresectable pancreatic cancer. /Cancer Chemother. Pharmacol./共著/2015.12
TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation. /Free Radic. Biol. Med./共著/2016.01
Clinical response to valproate in patients with migraine. /J. Clin. Neurol. /共著/2016.10
Effect of clonazepam and clonidine on primary sleep bruxism: a double-blind, crossover, placebo-controlled traial. /J Sleep Res./共著/2017.02
アプライド セラピューティクス3 /(株)じほう/-/
主な担当授業科目名 人体の構造と機能、病態生理学Ⅱ

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