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教員紹介

所属 ヒューマンケア学部 柔道整復学科 教授
氏名 内田 俊也
最終学歴 東京大学医学部医学科
現在所属している学会 日本内科学会、日本腎臓学会、日本痛風・核酸代謝学会、日本腎臓リハビリテーション学会、日本病態栄養学会
学士・修士・博士 医学博士
所有資格 医師免許、日本内科学会認定医、日本腎臓学会認定医、日本腎臓学会指導医、日本透析医学会専門医、日本透析医学会指導医、日本アフェレシス学会認定医、痛風専門医、日本高血圧学会認定医
研究の分野 内科系臨床医学 生物科学 農学
主な研究項目 慢性腎臓病の病態解明と治療介入,尿酸を基盤とした腎臓障害の機序の解明,低カリウム野菜の慢性腎臓病への応用
主な研究業績 CONTRIBUTIONS TO NEPHROLOGY /Kargar AG/共著/2018.01
Angiotensin II-induced phosphorylation of the sodium chloride cotransporter. / Kidney Int. 2011 Jun;79(12):1381-1382./共著/2011.06
Differential Diagnosis of Chronic Kidney Disease (CKD): By primary diseases. /JMAJ 2011;54: 22–26./単著/2011.11
Urinary stone analysis in a patient with hyperuricemia to determine the mechanism of stone formation. /Nucleosides Nucleotides Nucleic Acids. 2011 Dec;30(12):1072-6./共著/2011.12
Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages. /Am J Physiol - Renal Physiol. 2012 Aug 1;303(3):F339-F349./共著/2012.08
Primary polydipsia, but not accumulated ceramide, causes lethal renal damage in saposin D-deficient mice. /Am J Physiol - Renal Physiol. 2012 Oct;303(7):F1049-F1059./共著/2012.10
Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR). /Clin Exp Nephrol. 2012 Dec;16(6):903-20./共著/2012.12
The effect of febuxostat to prevent a further reduction in renal function of patients with hyperuricemia who have never had gout and are complicated by chronic kidney disease stage 3: study protocol for a multicenter randomized controlled study. /Trials. 2014 Jan 16;15:26./共著/2014.01
Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease. /Clin Exp Nephrol. 2014 Feb;18(1):50-5./共著/2014.02
A multicenter cross-sectional study of circulating soluble urokinase receptor in Japanese patients with glomerular disease. /Kidney Int. 2014 Mar;85(3):641-648./共著/2014.03
Mislocalization of K+ channels causes the renal salt wasting in EAST/SeSAME syndrome. /FEBS Lett. 2014 Mar 18;588(6):899-905./共著/2014.03
Proteomic analysis to examine the role of matrix proteins in a gouty tophus from a patient with recurrent gout. /Nucleosides Nucleotides Nucleic Acids. 2014;33(4-6):199-207./共著/2014.06
Clinical Image. Lack of blood flow in bilateral renal cortex. /JSM Clin Case Rep. 2014 Sep 29;2(5): 1054./共著/2014.09
Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. /Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15556-15561./共著/2014.10
Effects of the N/L-Type calcium channel blocker cilnidipine on nephropathy and uric acid metabolism in hypertensive patients with chronic kidney disease (J-CIRCLE Study). /J Clin Hypertens (Greenwich). 2014 Oct;16(10):746-753./共著/2014.10
Successful treatment of infectious endocarditis associated glomerulonephritis mimicking C3 glomerulonephritis in a case with no previous cardiac disease. /Case Rep Nephrol. 2014;2014:569047. /共著/2014.11
Combination of ACE inhibitor with nicorandil provides further protection in chronic kidney disease. /Am J Physiol - Renal Physiol. 2014 Dec 15;307(12):F1313-F1322./共著/2014.12
Anti-albuminuric effect of the aldosterone blocker eplerenone in non-diabetic hypertensive patients with albuminuria: a double-blind, randomised, placebo-controlled trial. /Lancet Diabetes Endocrinology 2014 Dec;2(12):944-953./共著/2014.12
Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout. /Clin Exp Nephrol. 2014 Dec;18(6):876-884./共著/2014.12
Acute Kidney Injury Facilitates Hypocalcemia by Exacerbating the Hyperphosphatemic Effect of Muscle Damage in Rhabdomyolysis. /Nephron. 2015;131(1):11-16./共著/2015.01
Immediate therapeutic efficacy of low-density lipoprotein apheresis for drug-resistant nephrotic syndrome: evidence from the short-term results from the POLARIS Study. /Clin Exp Nephrol. 2015 Jun;19(3):379-386./共著/2015.06
Blood pressure control and satisfaction of hypertensive patients following a switch to combined drugs of an angiotensin receptor blocker and a calcium channel blocker in clinical practice of nephrology. /Clin Exp Nephrol. 2015 Jun;19(3):465-473./共著/2015.06
Predictors and the subsequent risk of end-stage renal disease –Usefulness of 30% decline in estimated GFR over 2 years. /PLoS One. 2015 Jul 15;10(7):e0132927./共著/2015.07
Sonographic detection of a radiolucent object in dialysis vascular access. /J Clin Ultrasound. 2015 Jul-Aug;43(6):397-399./共著/2015.08
Sonographic detection of a radiolucent object in dialysis vascular access. /J Clin Ultrasound. 2015 Jul-Aug;43(6):397-399./共著/2015.08
A prospective observational survey on the long-term effect of LDL apheresis on drug-resistant nephrotic syndrome. /Nephron Extra. 2015 Aug 29;5(2):58-66./共著/2015.08
Prospective randomized study of the tolerability and efficacy of combination therapy for hypertensive chronic kidney disease: results of the PROTECT-CKD study. /Clin Exp Nephrol. 2015 Oct;19(5):925-932./共著/2015.10
ENOS deficiency causes podocyte injury with mitochondrial abnormality. /Free Radic Biol Med. 2015 Oct;87:181-192./共著/2015.10
Long-term efficacy of vildagliptin in patients with type 2 diabetes undergoing hemodialysis. /J Diabetes Metab Disord. 2015 Nov 5;14:83./共著/2015.11
Rapid deterioration of the renal function caused by the coexistence of intratubular amyloidosis and myeloma cast nephropathy. /Intern Med. 2015;54(23):3023-3028./共著/2015.12
Targeting uric acid and the inhibition of progression to end-stage renal disease -A propensity score analysis. /PLoS One. 2015 Dec 23;10(12):e0145506./共著/2015.12
Time-dependent risk factors associated with the decline of estimated GFR in CKD patients. /Clin Exp Nephrol. 2016 Feb;20(1):58-70./共著/2016.02
The impact of normal range of serum phosphorus on the incidence of end-stage renal disease by a propensity score analysis. /PLoS One. 2016 Apr 28;11(4):e0154469./共著/2016.04
Proteomics approach identifies factors associated with the response to LDL apheresis therapy in patients with steroid-resistant nephrotic syndrome. /Ther Apher Dial 2016 Apr;20(2):174-182./共著/2016.04
Pathological implications of linear immunoglobulin G staining on the glomerular capillary walls in a case of infection-related glomerulonephritis. /Pathol Int. 2016 Sep;66(9):524-528./共著/2016.09
Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 3. /Biochem Biophys Res Commun. 2016 Nov;480(4):745-751./共著/2016.11
Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury. / Nucleosides Nucleotides Nucleic Acids. 2016 Dec;35(10-12):543-549./共著/2016.12
Stimulation of V1a receptor increases renal uric acid clearance via urate transporters: Insight into pathogenesis of hypouricemia in SIADH. /Clin Exp Nephrol. 2016 Dec;20(6):845-852./共著/2016.12
Uric acid metabolism of kidney and intestine in a rat model of chronic kidney disease. /Nucleosides Nucleotides Nucleic Acids. 2016 Dec;35(10-12):550-558./共著/2016.12
Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain. /Fluids Barriers CNS. 2016 Dec 12;13(1):22./共著/2016.12
Podocyte injury and albuminuria in experimental hyperuricemic model rats. /Oxid Med Cell Longev. 2017;2017:3759153./共著/2017.02
Targeting gene expression to specific cells of kidney tubules in vivo, using adenoviral promoter fragments. /PLoS One. 2017 Mar 2;12(3):e0168638./共著/2017.03
Factors associated with unemployment in patients undergoing hemodialysis: a mixed methods study. /Renal Replacement Therapy. 2017;3:23./共著/2017.03
Mineralocorticoid receptor as a therapeutic target in chronic kidney disease and hypertension. /Hypertens Res. 2017 Mar;40(3):221-225./共著/2017.03
Time to target uric acid to retard CKD progression. /Clin Exp Nephrol. 2017 Apr;21(2):182-192./共著/2017.04
Renoprotective effect of topiroxostat via antioxidant activity in puromycin aminonucleoside nephrosis rats. /Physiol Rep. Vol. 5 no. e13358 /共著/2017.05
Hypokalemia and pendrin induction by aldosterone. /Hypertension. 2017 May;69(5):855-862./共著/2017.05
Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and 1 ATP-binding cassette sub-family G member 2. /Am J Physiol - Renal Physiol. 2017 Sep 1;313(3):F826-F834. /共著/2017.09
Unique proximal tubular cell injury and the development of acute kidney injury in adult patients with minimal change nephrotic syndrome. /BMC Nephrol.2017;18(1):339./共著/2017.11
Uric acid in the follow-up determines 30% decline in estimated GFR over 2 years: A propensity score analysis. /Kidney & Blood Pressure Res. 2017;42:1073-1087./共著/2017.12
Association of cholesterol efflux capacity with plasmalogen levels of high-density lipoprotein: a cross-sectional study in chronic kidney disease patients. /Atherosclerosis. 2018;270:102-109./共著/2018.02
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