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教員紹介

所属 薬学部 薬学科 教授
氏名 林 譲
最終学歴 東京大学大学院薬学系研究科 博士課程修了
現在所属している学会 日本薬学会
学士・修士・博士 薬学博士
所有資格
研究の分野 薬学
主な研究項目 自然と社会における異常の検出,薬局情報から推定する住民の健康,FUMI理論,物理系薬学
主な研究業績 Chapter 5. Information theory of signal resolution - precision of measurements, /The Handbook of Environmental Chemistry/共著/
Elution of bisphenol-A from hemodialyzers consisting of polycarbonate and polysulfone resins /J. Biomed Mater Res, 58 (2001) 209-215./共著/
Deductive prediction of precision and detection limit in bioluminescent measurement systems /Analytica Chimica Acta, 441 (2001) 243-248./共著/
Prediction of measurement precision based on FUMI theory for quantitative mass spectrometry with electron ionization /J. Mass Spectrom. Soc. Jpn. 48 (2000) 248-253./共著/
Prediction of measurement precision by chemometric invalidation of flow pulsation in refractive index detection of liquid chromatography /Anal. Sci., 15 (1999) 549-554./共著/
Deductive prediction of precision in measurement, calibration and standard addition method in atomic absorption spectrometry for cadmium /Analytical Chemistry, 70 (1998) 319-327./共著/
Routine check of baseline noise in ion chromatography /J. Chromatogr. A, 833 (1999) 97-104./共著/
Statistical and probabilistic approaches to confidence intervals of linear calibration in liquid chromatography /The Analyst, 126 (2001) 2061-2065./共著/
Validation of HPLC and GC/MS systems for bisphenol-A leached from hemodialyzers on the basis of FUMI theory /J. Pharm. Biomed. Anal., 28 (2002) 421-429./共著/
Prediction of precision based on FUMI theory and a single test  Effect of thickness of radial flow cell on electrochemical detection using micro HPLC  /ITE Letters, 4 (2003) C10-C14/共著/
Precision, limit of detection and range of quantitation in competitive ELISA /Analytical Chemistry, 76 (2004) 1295-1301./共著/
K. Fujishita, S. Ozawa, J. Sawada, K. Inoue, K. Shudo and Y. Hayashi, /Anal. Sci., 19 (2003) 1529-1535./共著/
Estimation of uncertainty in kinetic-colorimetric assay of bacterial endotoxins /J. Pharm. Biomed. Anal., 32 (2003) 495-503./共著/
Prediction of measurement precision of apparatus using a chemometric tool in electrochemical detection of high-performance liquid chromatography /J. Chromatogr. A, 986 (2003) 239-246. /共著/
Optimization of HPLC-ECD conditions for determination of catechins with precision and efficiency based on the FUMI theory /Anal. Sci., 19 (2003) 865-869./共著/
Discrimination limit for purity test of human insulin by capillary electrophoresis /J. Chromatogr. B, 703 (1997) 139-145./共著/
Precision-optimization of wavelengths in diode-array detection in separation science /Anal. Sci., 13 (1997) 951-962./共著/
Uncertainty structure of dilution with pipette and volumetric flask /Anal. Sci., 10 (1994) 881-888./共著/
Stochastic utility of internal standard method in liquid chromatography /Anal. Sci., 11 (1995) 389-400./共著/
Deductive prediction of measurement precision from signal and noise in photomultiplier and photodiode detector of liquid chromatography /Anal. Sci., 10 (1994) 725-730./共著/
Deductive prediction of measurement precision from signal and noise in liquid chromatography /Analytical Chemistry, 66 (1994) 2874-2881./共著/
Optimization of a liquid chromatographic method based on information theory: application of the method to dissolution testing /J. AOAC Int., 77 (1994) 338-343./共著/
Influence of integration domain on precision of measurements in liquid chromatography /Anal. Sci., 10 (1994) 553-559./共著/
Prediction of precision from signal and noise measurement in liquid chromatography: Limit of detection /Chromatographia, 41 (1995) 66-74./共著/
Prediction of precision from signal and noise measurement in liquid chromatography: Mathematical relationship between integration domain and precision /Chromatographia, 41 (1995) 75-83./共著/
Probabilistic approach to confidence intervals of linear calibration /The Analyst, 121 (1996) 591-599./共著/
Measurement of uncertainty and discrimination limit in purity tests of drug quality /J. Pharm. Boimed. Anal., 15 (1997) 697-708./共著/
Measurement precision and 1/f noise in analytical instruments /J. Chromatogr. A, 722 (1996) 157-167./共著/
Deductive prediction of measurement precision and optimization of integration time and wavelength in capillary electrophoreses /Chromatographia, 41 (1995) 707-714./共著/
Deductive prediction of measurement precision from signal and noise in fluorometry /Anal. Sci., 11 (1995) 929-934./共著/
Risk assessment of di(2-ethylhexyl)phthalate eluted from PVC blood circuits during hemodialysis and pump-oxygenation therapy /Int. J. Pharm. 274 (2004) 119-129./共著/
Improvement in reliability of probabilistic test of significant differences in GeneChip experiments /Anal. Sci., 20 (2004) 731-733/共著/
高速液体クロマトグラフィー分析の精度と検出限界に関する共同実験 /分析化学,48 (1999) 265-269./共著/
クロマトグラフィー分析における適切なデータ取り込み間隔の推定 /分析化学,49 (2000) 225-231./共著/
高速液体クロマトグラフィーにおける検出下限の推定法の比較 /分析化学,47 (1998) 267-271./共著/
情報理論に基づいたN-メチルカルバメート系農薬の高速液体クロマトグラフィー分離の最適化 /分析化学,42 (1993) 881-886/共著/
生薬学を楽しく学ぶソフトウェア /帝京平成大学紀要 第22巻 第2号 (2011) 23-28/共著/
マルチCPUシステムで制御された簡易型化学発光測定装置の試作 /衛生試験所報告,104 (1986) 35-38./共著/
クロマトグラフィー分析における適切なデータ取り込み間隔とデータ処理に関する考察 /分析化学,49 (2000) 233-238./共著/
化学教育における平衡をめぐる理解と誤解について /上越教育大学研究紀要,19 (2000) 461-471./共著/
システム適合性試験の不適合システムの検出力に関する考察 /医薬品研究,36 (2005) 433-436/共著/
薬局の薬剤処方量の解析からインフルエンザ伝播パターンを知る試み /国立医薬品食品衛生研究所報告,124 (2006) 56-59./共著/
競合ELISA法の検出限界をB/B0曲線の傾きから求める方法 /薬学雑誌,125 (2005) 323-325/共著/
クロマトグラムの積分法が測定値の真度・精度へ与える影響 /分析化学,52 (2003) 589-595. /共著/
システム適合性試験における精度の推定 /薬学雑誌, 122 (2002) 849-854./共著/
HPLC分析における内標準法の有効性について /薬学雑誌,123 (2003) 349-355./共著/
Prediction of measurement uncertainty in isotope dilution Gas Chromatography/Mass Spectrometry /J. Chromatogr. A, 1136 (2006) 226-230. /共著/
Birth-and-death process of computer viruses /Bulletin of National Institute of Health Sciences, 124 (2006) 60-61./共著/
Stochastic properties of prescriptions for infectious and non-infectious diseases dispensed at a city pharmacy /Jpn. J. Pharm. Health Care Sci., 32 (2006) 51-54./共著/
A method for estimating infection route and speed of influenza /Yakugaku Zasshi, 126 (2006) 161-165./共著/
New approaches to mechanism analysis for drug discovery using DNA microarray data combined with KeyMolnet /Current Drug Discovery Technologies, 2 (2005) 89-98./共著/
Detection limit estimated from slope of calibration curve: An application to competitive ELISA /Anal. Sci., 21 (2005) 167-169./共著/
An expression of within-plate uncertainty in sandwich ELISA /J. Pharm. Biomed. Anal., 36 (2004) 225-229./共著/
Precision and detection limit of quality test for amorphous drug in powder X-ray diffractometry /Int. J. Pharm. 283 (2004) 63-69./共著/
A method for detecting injury of people’s health from prescriptions at a pharmacy /Yakugaku Zasshi, 126 (2006) 283-287./共著/
A method for estimating the order of influenza infection between adults and children /Yakugaku Zasshi, 126 (2006) 311-314./共著/
Smoothing of Correlation Functions in the Estimation of the Order of Influenza Infection between Adults and Children /J. Health Sci., 52 (2006) 435-442./共著/
Quantitative epidemiological understanding of influenza propagation process in Tokyo and environs /J. Health Sci., 52 (2006) 637-641. /共著/
Stochastic study on the sales pattern of influenza anti-viral agents at pharmacies /J. Health Sci., 52 (2006) 431-435./共著/
Classification of drugs according to stochastic properties of drug supply at a pharmacy /Jpn. J. Pharm. Health Care Sci., 32 (2006) 489-496./共著/
An expression of uncertainty in calibration using stepwise or separate dilution of a stock solution /Anal. Sci., 22 (2006) 889-894./共著/
Information theory of miniaturization advantages of column liquid chromatography for quantitative analysis /Fresenius' Journal of Analytical Chemistry, 347 (1993) 225-229./共著/
Information-based prediction of the precision and evaluation of the accuracy of the results from an adaptive filter /Chemometrics and Intelligent Laboratory Systems, 20 (1993) 163-171./共著/
Real-time quantitative analysis of unresolved liquid chromatographic peaks with the use of the Kalman filter /Journal of Chromatography, 407 (1987) 59-64./共著/
Resolution of overlapped chromatograms by means of the Kalman filter. Dimensional reduction of error covariance matrices and state estimate vectors /Analytica Chimica Acta, 201 (1987) 185-191./共著/
Determination of cholesterol with a laboratory-built chemiluminescence system /Analytica Chimica Acta, 188 (1986) 95-100./共著/
Study on some factors affecting the precision of luminescence analyses /Chemical & Pharmaceutical Bulletin, 34 (1986) 3475-3480./共著/
Computerized analyzing system for chemiluminescence /Chemical & Pharmaceutical Bulletin, 32 (1984) 3079-3087./共著/
Rapid chemiluminescence measurements by digital processing of signals and smoothing by Fourier transform /Analytica Chimica Acta, 167 (1985) 81-88./共著/
Resolution of overlapped chromatograms by means of the Kalman filter. Data processing of liquid chromatographic signals without solvent peaks /Analytica Chimica Acta, 202 (1987) 187-197./共著/
Resolution of overlapped chromatograms by the use of a Kalman filter. III. Effects of overlapping and outstripping of a solvent peak on the analysis /Journal of Chromatography, 411 (1987) 95-105./共著/
An information theory of chromatography. /Journal of Chromatography, 462 (1989) 13-21./共著/
An information theory of chromatography /Journal of Chromatography, 462 (1989) 23-30./共著/
Application of gel permeation chromatograph-low angle laser light scattering system to kinetic study on degradation of bioerodible polymers /Chemical & Pharmaceutical Bulletin, 36 (1988) 4951-4957./共著/
A one-dimensional Kalman filter for peak resolution /Analytica Chimica Acta, 212 (1988) 81-94./共著/
Totally automated robotic system for liquid chromatographic analysis of solid dosage formulations with the aid of a reduced Kalman filter /Journal of Chromatography, 438 (1988) 319-327./共著/
One-dimensional Kalman filter in a robot system for total analysis of solid dosage formulations /Analytica Chimica Acta, 209 (1988) 45-55./共著/
Hydrogen exchange kinetics of nucleic acids. Double and triple helices with Hoogsteen-type basepairs /Biochimica et Biophysica Acta, 698 (1982) 93-99./共著/
Hydrogen-exchange kinetics in a double-helical polynucleotide with the adenine-uracil basepair. A use of the N6-methyladenine residue /Biochimica et Biophysica Acta, 656 (1981) 120-122./共著/
Geographical pattern of influenza propagation in Tokyo and its neighborhood in three seasons /J. Health Sci., 53 (2007) 722-729/共著/
Baseline noise and measurement uncertainty in liquid chromatography /Anal. Sci., 23 (2007) 1077-1080/共著/
Detection limit of measurement of pharmaceuticals labeled with short-lived isotopes in HPLC with flow-through -counter /J. Pharm. Biomed. Anal., 46 (2008) 177-180/共著/
Factor analysis of drug supply time series at pharmacies /J. Health, Sci., 54 (2008) 107-111/共著/
Detection limit used for early warning in public health surveillance /Anal. Sci., 25 (2009) 795-800/共著/
Optimization of capillary liquid chromatography with electrochemical detection for determining femtogram levels of baicalin and baicalein on the basis of the FUMI theory /J. Pharm. Biomed. Anal., 48 (2008) 780-787/共著/
Simulation model for predicting limit of detection and range of quantitation of competitive enzyme-linked immunosorbent assay /Journal of Bioscience and Bioengineering, 103 (2007) 427-431/共著/
Validation of a method for predicting the precision, limit of detection and range of quantitation in competitive ELISA /Anal. Sci., 23 (2007) 215-218/共著/
Hydrogen-deuterium exchange studies of proteins and nucleic acids /Biophysical Journal, 32 (1980) 621-623./共著/
Hydrogen exchange kinetics and microscopic environments of the uracil and adenine residues /Nucleic Acids Research, Symposium Series, 10 (1981) 119-122./共著/
Hydrogen-deuterium exchange kinetics in a triple-helical polynucleotide /Chemistry Letters, (1980) 495-498./共著/
欧米における利益相反の取り扱いに関する調査及び日本における産学連携活動に対する医師及び薬剤師の意識調査に関する研究 /国立医薬品食品衛生研究所報告,126 (2008) 111-119/共著/
薬局の在庫管理に対するFUMI理論の応用に関する研究 /社会薬学,27 (2009) 7-16/共著/
Epimerization and hydrolysis of etoposide analogues in aqueous solution /Chemical & Pharmaceutical Bulletin, 37 (1989) 422-424./共著/
Shannon information retrieved from overlapped chromatographic peaks with Kalman filter /Anal. Sci., 5 (1989) 329-334./共著/
Mathematical structure of chromatographic optimization based on information theory: /Chromatographia, 31 (1991) 374-380./共著/
Feasible solutions of optimization problems involving unresolved component peaks with the aid of retention prediction and information theory /Chromatographia, 31 (1991) 554-560./共著/
Mathematical structure of chromatographic optimization based on information theory: /Chromatographia, 31 (1991) 367-373./共著/
Information theory of precision and analytical efficiency in short-column chromatographic assays /Anal. Sci., 7 (1991) 329-331./共著/
Information theory of optimization in chromatography: /Journal of Chromatographic Science, 29 (1991) 60-65./共著/
Chromatographic optimization of flow rate and column length based on information theory /Anal. Sci., 7 (1991) 9-13./共著/
Simplex optimization of liquid chromatography with the function of mutual information as a criterion /Journal of Chromatography, 585 (1991) 187-193./共著/
Information theory of optimization in chromatography: /Chromatographia, 32 (1991) 233-237./共著/
Optimization of precision and throughput in micellar electrokinetic chromatography /Chromatographia, 37 (1993) 149-155./共著/
An information theory-based evaluation of stationary phases developed for optical resolution of amino acids /Chromatographia, 37 (1993) 156-158./共著/
Information theory of chromatography and titration /Analytica Chimica Acta, 277 (1993) 325-331./共著/
Accuracy, precision and information of the adaptive Kalman filter in chromatography /Analytica Chimica Acta, 271 (1993) 91-100./共著/
Optimization based on retention prediction and information theory for liquid-chromatographic analysis of alkylbenzenes /Analytical Letters, 24 (1991) 2083-2091./共著/
Information theory of optimization in chromatography: /Chromatographia, 30 (1990) 371-376./共著/
A simple optimization strategy based on Rs-minimum and information theory of chromatography /Chromatographia, 30 (1990) 367-370./共著/
Short column advantage justified by information theory of optimization in chromatography /Anal. Sci., 6 (1990) 131-133./共著/
Optimal peak separation derived from information theory of chromatography /Anal. Sci., 6 (1990) 257-260./単著/
Information theory of optimization in chromatography /Anal. Sci., 6 (1990) 15-19./共著/
Optimization of detection wavelengths in liquid chromatography on the basis of information theory and Kalman filter /Anal. Sci., 5 (1989) 459-464/共著/
Use of a function of mutual information for optimization of mobile phase composition in reversed phase liquid chromatography /Analytica Chimica Acta, 222 (1989) 301-312./共著/
Modification of the function of mutual information based on information theory and the Kalman filter for chromatographic optimization /Analytica Chimica Acta, 222 (1989) 313-322./共著/
Information theory of optimization in chromatography: /Chromatographia, 29 (1990) 446-448./共著/
Information theory of column chromatography on the basis of the information measure FUMI /Journal of Chromatography, 513 (1990) 349-353./共著/
Information theory of optimization in chromatography: /Fresenius' Journal of Analytical Chemistry, 338 (1990) 597-601./共著/
Quantity and wavelength optimization based on information theory of chromatography /Journal of Chromatographic Science, 28 (1990) 628-632./共著/
Comparison of optimization based on information theory with optimization of Rs in column chromatography /Analytical Letters, 23 (1990) 1765-1781./共著/
Total chromatographic optimization (TOCO). /Chromatographia, 30 (1990) 171-175./共著/
Total chromatographic optimization (TOCO). /Chromatographia, 30 (1990) 85-90./共著/
Selection of the optimal solvent grade for the mobile phase in HPLC with electrochemical detection based on FUMI theory /Anal. Sci., 25 (2009) 925-929/共著/
インフルエンザの伝播と薬剤使用量の関係,薬剤師の社会的役割 /薬局薬学,1(2009)5-10/単著/
ELISAにおける精度・検出限界の推定法 /日薬理誌(Folia Pharmacol. Jpn.), 134(2009)207-211/共著/
バイオテロに対する薬剤師の役割 /社会薬学会誌 27(2008)11-18/共著/
ヘルスヴィジランスの情報源としての薬局 /医薬品情報学 9 (2008) 236-242./共著/
Optimization theory of chromatography /Chemometrics and Intelligent Laboratory Systems, 18 (1993) 1-16./共著/
Five methods for determining the limit of detection in instrumental analyses /American Biotechnology Laboratory, 20 (2002) 20-22./共著/
Expression of uncertainty in measurement and its application to liquid chromatography with electrochemical detection /Trends in Chromatography, 2 (2006) 69-81./共著/
Hydrogen-deuterium exchange kinetics of a double-helical nucleic acid as examined by stopped-flow ultraviolet spectroscopy /Proceedings of the Third International Symposium, Division of Biophysics, The Taniguchi Foundation (M. Kotani and A. Wada, eds.), pp. 189-216 (1977)./共著/
Resolving unmodeled components from U.V.-visible spectra with adaptive filtering /the Proceedings of the 4th Symposium on Computer-Enhanced Analytical Spectroscopy, pp. 257-274 (1994) Chapter 11, Plenum Publishing Co./共著/
Baseline noise in high-performance liquid chromatography with electrochemical detection /Noise and Fluctuations: 18th International Conference on Noise and Fluctuations/共著/
薬剤使用量に基づいたヘルスヴィジランスシステムによる新型インフルエンザの流行推定 /日薬理誌(Folia Pharmacol. Jpn.)136(2010) 310/共著/
分析化学におけるKalman Filter /ファルマシア,23 (1987) 935./単著/
Chemometrics:液体クロマトグラフィの実験条件の最適化はどのようになされているか /ファルマシア,25 (1989) 1256/単著/
コンピューターを用いたクロマトグラフィーの最適化の動向 /ぶんせき,(1990) 901-903./共著/
情報理論に基づいたクロマトグラフィーの最適化理論:FUMIとTOCO /ぶんせき,(1991) 57-61./共著/
分析機器における1/f揺らぎと定量精度 /ぶんせき,(1995) 195-200./共著/
化学理論[活動紹介] TOCOの会の活動紹介  /化学教育ジャーナル (CEJ),2(2),(1998)./共著/
遺伝子発現を指標とする化学物質の安全性評価法に関する研究 /国立医薬品食品衛生研究所報告,121 (2003) 122-123./共著/
FUMI理論を活用した電気化学検出HPLCシステムの最適化 /Review of Polarography,50 (2004) 109-123.//
国立医薬品食品衛生研究所における基盤ネットワークの現状について /国立医薬品食品衛生研究所報告,122 (2004) 34-36./共著/
ELISA分析における不確かさ,検出限界と定量限界 /第4回エキスパートワークショップ実践コース(ELISA)のテキスト,日本分析化学会,2004/共著/
薬剤師が看る国民の健康状態~ヘルスヴィジランス~  /薬局,57 (2006) 3145-3150./共著/
薬の販売量から推定するインフルエンザ感染の経路と速度 /ファルマシア,42 (2006) 1246-1251./共著/
薬局の持っている情報はどのように利用できるか? /第1回 薬局情報の特徴,表示と解釈/共著/
薬剤師が看る国民の健康状態~ヘルスヴィジランス~  /薬局,58 (2007) 113-116./共著/
薬剤師が看る国民の健康状態~ヘルスヴィジランス~  /薬局,58 (2007) 493-498./共著/
薬局の持っている情報はどのように利用できるか? /レシピ,6 (2007) 173-175/共著/
薬剤師が看る国民の健康状態~ヘルスヴィジランス~  /薬局,58 (2007) 2330-2333./共著/
薬剤師が看る国民の健康状態~ヘルスヴィジランス~  /薬局,58 (2007) 2479-2484./共著/
薬局の持っている情報はどのように利用できるか? /レシピ,6 (2007) 282-284./共著/
薬剤師が看る国民の健康状態~ヘルスヴィジランス~  /薬局,58 (2007) 2827-2830./共著/
薬局の持っている情報はどのように利用できるか? /レシピ,6 (2007) 364-366./共著/
薬局のデータを使って地域住民の健康管理を! /RAD-AR News, 18 (2007) 16-17. /単著/
Perception of physicians, pharmacists and pharmaceutical industries about information in package inserts in Japan /Jpn. J. Drug Inform. 14(1):2-13 (2012)/共著/
The relationship between academic achievement and ability of the experiment /Proceedings of the 10th ANQ Congress (2012)/共著/
主な担当授業科目名 化学系実習I、薬学基礎実習

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