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教員紹介

所属 薬学部 薬学科 准教授
氏名 後藤 芳邦
最終学歴 東京農工大学大学院連合農学研究科生物工学専攻博士後期課程修了
現在所属している学会 日本生化学会
学士・修士・博士 学士(工学)、修士(工学)、博士(農学)
所有資格
研究の分野 生物科学(機能生物化学)、薬学(生物系薬学)、基礎医学(免疫学)、
主な研究項目 アミノペプチダーゼによるマクロファージの活性化機構の解明,アミノペプチダーゼの酵素学的性状の解明,アミノペプチダーゼによる精神調節機構の解明
主な研究業績 Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L(査読付) /EMBO J., 23, 3929-3938/共著/2004.01
Molecular basis for recognition of 2',5'-linked oligoadenylates by the N-terminal ankyrin repeat domain of human ribonuclease L(査読付) /Nucleic Acids Symp. Ser. (Oxford), 49,323-324 /共著/2005.01
2-5A induces a conformational change in the ankyrin-repeat domain of RNase L(査読付) /Proteins, 60,131-138/共著/2005.01
Crystallization of the N-terminal ankyrin repeat domain of the 2-5A-dependent endoribonuclease,RNase L(査読付) /Protein. Pept., Lett., 12,387-389/共著/2005.01
Reduced activity of hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1(査読付) /FEBS Lett., 580,1833-1838/共著/2006.01
Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin Ⅳ(査読付) /J. Biol. Chem., 280, 23503-23513/共著/2006.01
Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatlc activity of human aminopeptidase A(査読付) /J. Biol. Chem., 282,37074-37081/共著/2007.01
Laeverin/Aminopeptidase Q,a Novel Bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases(査読付) /J. Biol. Chem., 282,20088-20096/共著/2007.01
Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic-reticulum aminopeptidase-1(査読付) /Biochem. J.,16,109-116/共著/2008.01
Histidine-379 of human laeverin/aminopeptidase Q, a non-conserved residue within the exopeptidase motif, defines its distinctive enzymatic properties(査読付) /J. Biol. Chem. 284, 34692-34702/共著/2009.10
Involvement of Gln-238 in the substrate specificity of human laeverin/aminopeptidase Q(査読付) /Biol. Pharm. Bull., 34, 24-27/共著/2011.01
Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme(査読付) /J. Immunol., 186, 1909-1913/共著/2011.01
Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma(査読付) /J. Biol. Chem., 286, 21906-21914/共著/2011.06
Exon 10 coding sequence is important for endoplasmic reticulum retention of endoplasmic reticulum aminopeptidase 1(査読付) /Biol. Pharm. Bull., 35, 601-605/共著/2012.04
TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages(査読付) /J. Immunol., 192, 4443-4452/共著/2014.05
Role of glutamine-169 in the substrate recognition of human aminopeptidase B(査読付) /Biochim. Biophys. Acta, 1840, 1872-1881/共著/2014.06
Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages /J. Biochem. 157, 439-449/共著/2015.06
Involvement of Phenylalanine 297 in the Construction of the Substrate Pocket of Human Aminopeptidase B /Biochemistry, 54, 6062-6070/共著/2015.10
A Single Neonatal Injection of Ethinyl Estradiol Impairs Passive Avoidance Learning and Reduces Expression of Estrogen Receptor α in the Hippocampus and Cortex of Adult Female Rats /PLoS One, 11, e0146136/共著/2016.01
(総説・解説)Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure(査読付) /Heart Fail. Rev., 13, 285-291/共著/2007.01
医薬としてのアミノペプチダーゼ阻害剤の可能性(査読付) /ファルマシア,45,715-716/単著/2009.01
主な担当授業科目名 薬学基礎実習、臨床薬学実習Ⅱ、卒業研究、生物系薬学概論I

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