島村 道夫
Faculty

学部・大学院

島村 道夫

所属 健康メディカル学部 健康栄養学科 教授
最終学歴 東京大学大学院理学系研究科生物化学専攻博士課程修了
現在所属している学会 日本生化学会、日本免疫学会、日本化学会、日本薬学会
学士・修士・博士 理学士(東京大学)・理学修士(東京大学大学院)・理学博士(東京大学大学院)
所有資格 第1種放射線取扱主任者免許
研究の分野 生物科学(機能生物化学)基礎医学(免疫学)
主な研究項目 病原性微生物が産生するコレステロール配糖体の免疫系による認識機構の解明
主な研究業績 Invariant natural killer T cells stimulated with cholesteryl glycosides modulate immune responses in allergy and delayed-type hypersensitivity./European Journal of Immunology, 49: 348-350/共著/2019.02
Activation of invariant natural killer T cells stimulated with microbial α-mannosyl glycolipids/Scientific Reports, 7: 9703/共著/2017.08
Immunological functions of steryl glycosides./Archivum Immunologiae et Therapiae Experimentalis, 60: 351-359 I/単著/2012.09
Therapeutic potential of cholesteryl O-acyl α-glucoside found in Helicobacter pylori./Curr. Med. Chem. 19: 4869-4874/共著/2012.08
Regulation of immunological disorders by invariant Vα19-Jα33 TCR-bearing cells./Immunobiol., 216: 374-378/共著/2011.09
Modulation of immunoglobulin production by invariant Vα19-Jα33 TCR-bearing cells./PLoS ONE, 6: e20915/共著/2011.06
Influenza A infection in suckling mice expands a population of NKT cells that protects mice as adults from airway hyperreactivity./J. Clin. Invest. 121: 57-69/共著/2011.01
Altered production of immunoregulatory cytokines by invariant Vα19 TCR-bearing cells dependent on the duration and intensity of TCR engagement./Int. Immunol. 29: 179-185/共著/2009.11
Glycolipids with non-reducing end a-mannosyl residues that have potentials to activate invariant Va19 NKT cells./FEBS. J., 274: 2921-2932/共著/2007.11
Modulation of Vα19 NKT cell immune responses by a-mannosyl ceramide derivatives consisting of a series of modified sphingosine./Eur. J. Immunol. 37: 1836-1844/共著/2007.07
Invariant Vα19i T cells regulate autoimmune inflammation.Modulation of immunoglobulin production by invariant Vα19-Jα33 TCR-bearing cells./Nature Immunol., 7: 987-994/共著/2006.07
Synthetic α-mannosyl ceramide as a potent stimulant for a novel NKT cell repertoire bearing the invariant Vα19-Jα26 TCR α chain./Chemistry & Biology, currently, Cell Chemical Biology, 12: 677-683/共著/2005.06
Generation of Va14 NKT cells in vitro from hematopoietic precursors residing in bone marrow and peripheral blood./Eur. J. Immunol., 34:735-742/共著/2004.05
Antibody production in early life supported by maternal lymphocyte factors./Biochim. Biophys. Acta, Molecular Basis of Diseases, 1637:55-58/共著/2003.09
Presence of a novel subset of NKT cells bearing an invariant Va19.1-Ja26 TCR a chain./FEBS Letters, 516: 97-100/共著/2002.04
Major sites for the development of Vα14+ NKT cells inferred from the V-J junctional sequences of the invariant T cell receptorα-chain./Eur. J. Biochem., 268: 56-61/共著/2001.10
Two independent pathways of maternal cell transmission to offspring; through placenta during pregnancy and by breast-feeding after birth./Immunology, 101: 570-580/共著/2000.12
Positive selection of NKT cells by CD1+, CD11c+ non-lymphoid cells residing in the extrathymic organs./Eur. J. Immunol., 29: 3962-3970/共著/1999.11
Lack of directed Va14-Ja281 rearrangements in NK1+T cells./Eur. J. Immunol., 27:1576-1579/共著/1997.09
Thymus-independent generation of NK1+ T cells in vitro from fetal liver precursors./J. Immunol., 158: 3682-3687/共著/1997.07
Germ-line transcription of T cell receptor gamma-delta gene found in mouse hematopoietic cell lines./Eur. J. Immunol., 25: 1541-1546/共著/1995.04
Transmission of maternal blood cells to the fetus during pregnancy: Detection in mouse  neonatal spleen by flow cytometry and polymerase chain reaction./Blood , 83: 926-930/共著/1994.02
主な担当授業科目名 生化学実験、分子栄養生物学、微生物・免疫、栄養生化学特論(大学院)