山本 伸一郎
Faculty

学部・大学院

山本 伸一郎

所属 薬学部 薬学科 准教授
最終学歴 京都大学大学院工学研究科合成・生物化学専攻博士課程 単位取得満期退学
現在所属している学会 日本薬学会、日本薬理学会
学士・修士・博士 博士 (工学) (京都大学) (2008年10月)
所有資格 薬剤師免許
研究の分野 医歯薬学 生物学
主な研究項目 カルシウムシグナリング 、タンパク質品質管理機構
主な研究業績 Significance of TRP channels in oxidative stress/European Journal of Pharmacology/共著/2016.12
Targeting TRPM2 in ROS-coupled diseases/Pharmaceuticals (Basel)/共著/2016.09
TRPM2/炎症と免疫/共著/2011.09
カルシウム放出チャネルとしての TRPM2 の β細胞における役割/日本薬理学雑誌/共著/2011.05
Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels./Progress in Biophysics and Molecular Biology/共著/2010.09
小胞体 Ca2+ 放出におけるTRICチャネルの生理的役割/日本薬理学雑誌/共著/2010.03
TRP チャネルの構造と多様な機能/日本生化学雑誌/共著/2009.11
酸化ストレス作動性 TRP チャネルの化学生理学/実験医学増刊/共著/2009.09
TRPM2 チャネルによる活性酸素シグナル増幅と慢性炎症の関連/日本薬理学雑誌/共著/2009.03
環境応答を担うイオンチャネル 活性化学種により活性化される TRP チャネルの分子機構/蛋白質核酸酵素/共著/2009.03
Transient receptor potential channels in Alzheimer's disease./Biochimica et Biophysica Acta/共著/2007.08
Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition./Journal of Pharmacology and Experimental Therapeutics/共著/2019.02
Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses./Journal of Pharmacological Sciences/共著/2017.05
Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activation/European Journal of Pharmacology/共著/2016.09
TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation/Free Radical Biology and Medicine/共著/2016.01
Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe2+ in human monocytic U937 cells./The International Journal of Biochemistry & Cell Biology/共著/2015.11
Prevention of aberrant protein aggregation by anchoring the molecular chaperone alphaB-crystallin to the endoplasmic reticulum./Biochemical and Biophysical Research Communications/共著/2014.12
Contribution of calumin to embryogenesis through participation in the ER-associated degradation activity./Developmental Biology/共著/2014.09
TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells./Journal of Biological Chemistry/共著/2012.09
The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death./Cell Calcium/共著/2012.02
TRPA1 underlies a sensing mechanism for O2./Nature Chemical Biology/共著/2011.10
TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance./Cell Metabolism/共著/2011.08
TRPM2 functions as lysosomal Ca2+ release channel in β-cells./Science Signaling/共著/2009.05
Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators./Channels/共著/2008.08
TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration./Nature Medicine/共著/2008.07
Nitric oxide activates TRP channels by cysteine S-nitrosylation./Nature Chemical Biology/共著/2006.11
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells./Free Radical Biology and Medicine/共著/2003.05
Stimulation of tetrahydrobiopterin synthesis by basic fibroblast growth factor in vascular endothelial cells./Pteridines/共著/2003.02
Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells./International Journal of Biochemistry and Cell Biology/共著/2002.09
Stimulation of tetrahydrobiopterin synthesis by cyclosporin A during lipopolysaccharide treatment in vascular endothelial cells./Pteridines/共著/2002.08
Hydrogen peroxide stimulates the LPS-induced tetrahydrobiopterin synthesis in mouse brain microvascular endothelial cells./Pteridines/共著/2002.02
Short TRPM2 prevents the targeting of full-length TRPM2 to the surface transmembrane by hijacking to ER associated degradation/Biochemical and Biophysical Research Communications/共著/2019.10
主な担当授業科目名 薬理学Ⅳ、生物系実習Ⅱ