戸田 雄大
Faculty

学部・大学院

戸田 雄大

所属 薬学部 薬学科 講師
最終学歴 星薬科大学大学院薬学研究科医療薬科学専攻 博士課程後期 修了
現在所属している学会 日本薬学会、日本薬理学会
学士・修士・博士 学士(薬学)、 修士(薬学)、 博士 (薬学)
所有資格 薬剤師免許
研究の分野 医歯薬学 薬理学
主な研究項目 TRPM2の機能解析と阻害剤の探索・応用
主な研究業績 Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition./J. Pharmacol. Exp. Ther., 368 246-254/共著/2019.02
Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses.(査読付き)/J. Pharmacol. Sci., 134 68-74/共著/2017.05
Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activation.(査読付き)/Eur. J. Pharmacol., 786 19-28/共著/2016.09
TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation.(査読付き)/Free Radic. Biol. Med., 90 101-113/共著/2016.01
Serotonergic mechanisms are involved in antidepressant-like effects of bisbenzylisoquinolines liensinine and its analogs isolated from the embryo of Nelumbo nucifera Gaertner seeds in mice.(査読付き)/J. Pharm. Pharmacol., inpress, doi: 10.1111/jphp.12473/共著/2015.12
Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe(2+) in human monocytic U937 cells.(査読付き)/Int. J. Biochem. Cell Biol., 16 119-127/共著/2015.11
Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry. (査読付き)/Eur, J, Pharmacol., 742C, 22-30/共著/2014.11
Gastrectomy increases the expression of hepatic cytochrome P450 3A by increasing lithocholic acid-producing enteric bacteria in mice.(査読付き)/Biol Pharm Bull., 37, 298-305/共著/2014.11
Total gastrectomy may result in reduced drug effectiveness due to an increase in the expression of the drug-metabolizing enzyme Cytochrome P450, in the liver.(査読付き)/Eur J Pharm Sci., 51, 180-188/共著/2014.01
A novel aromatic carboxylic Acid inactivates luciferase by acylation of an enzymatically active regulatory lysine residue.(査読付き)/PLoS One, 16, e75445/共著/2013.09
Synthesis of am80 (tamibarotene) prodrug candidates, congeners and metabolites.(査読付き)/Chem Pharm Bull. 61, 846-852/共著/2013.08
Different diets cause alterations in the enteric environment and trigger changes in the expression of hepatic Cytochrome P450 3A, a drug-metabolizing enzyme.(査読付き)/Biol. Pharm. Bull. 36, 624-634/共著/2013.02
Consumption of a high-fat diet during pregnancy changes the expression of cytochrome P450 in the livers of infant male mice.(査読付き)/Biol. Pharm. Bull. 36, 649-657/共著/2013.01
(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects.(査読付き)/Bioorg. Med. Chem. Lett., 22, 7602-7604/共著/2012.12
Consumption of a high-fat diet during pregnancy decreases the activity of cytochrome P450 3a in the livers of offspring.(査読付き)/Eur. J. Pharm. Sci., 47, 108-116/共著/2012.08
Inhibition of aquaporin-3 water channel in the colon induces diarrhea.(査読付き)/Biol. Pharm. Bull., 35, 957-962/共著/2012.06
Effect of Conclevan on endurance capacity in mice.(査読付き)/Biol. Pharm. Bull., 35, 231-238/共著/2012.02
Inhibition of preadipocyte differentiation and lipid accumulation by Orengedokuto treatment of 3T3-L1 cultures.(査読付き)/Phytother. Res., 26, 91-100/共著/2012.01
Inhibitory effect of polyphenol-rich fraction from the bark of Acacia mearnsii on itching associated with allergic dermatitis.(査読付き)/Evid. Based Complement. Alternat. Med., doi: 10.1155/2012/120389/共著/2012.01
The concomitant use of an osmotic laxative, magnesium sulphate, and a stimulant laxative, bisacodyl, does not enhance the laxative effect.(査読付き)/Eur. J. Pharm. Sci., 45, 73-78/共著/2012.01
Gypsum fibrosum and its major component CaSO4 increase cutaneous aquaporin-3 expression levels.(査読付き)/Ethnopharmacol., 31, 409-413/共著/2012.01
Anti-obesity and anti-diabeticeffects of acacia polyphenol in obese diabetic KKAy mice fed high-fat diet. (査読付き)/Evid. Based Complement. Alternat. Med., (2011) doi: 10.1093/ecam/nep241./共著/2011.04
Increases in the expression levels of aquaporin-2 and aquaporin-3 in the renal collecting tubules alleviate dehydration associated with polyuria in diabetes mellitus.(査読付き)/Biol., Pharm. Bull, 33, 1965-1970/共著/2010.12
The role of renal aquaporin 2 in the alleviation of dehydration associated with diabetic polyuria in KKAy mice.(査読付き)/Life Sci, 87, 475-480/共著/2010.08
Differences in the pharmacokinetics of Cyp3a substrates in TSOD and streptzotocin-induced diabetic mice.(査読付き)/Xenobiotica, 40, 282-290/共著/2010.04
Altered expression of CYP in TSOD mice: a model of type 2 diabetes and obesity.(査読付き)/Xenobiotica, 39, 889-902/共著/2009.12
Ciprofloxacin suppresses Cyp3a in mouse liver by reducing lithocholic acid-producing intestinal flora.(査読付き)/Drug Metab. Pharmacokinet., 24, 201-208/共著/2009.07
抗生物質を投与するとリトコール酸産生菌の減少に伴ってマウスの肝臓におけるCyp3aが減少する。(査読付き)/Yakugaku Zasshi, 129, 601-608/共著/2009.05
Intestinal flora induces the expression of Cyp3a in the mouse liver.(査読付き)/Xenobiotica, 39, 323-334/共著/2009.04
Effect of hydrocotarnine on cytochrome P450 and P-glycoprotein. (査読付き)/Drug Metab. Pharmacokinet., 24, 108-113(2009)/共著/2009.02
漢方専門外来受診患者における漢方薬服用に関する実態調査(1) 漢方薬と西洋薬の併用.(査読付き)/医療薬学, 33, 353-358/共著/2007.06
Juzentaihoto reduces post-partial hepatectomy hyperammonemia by stabilizing intestinal microbiota.(査読付き)/J. Trad. Med., 23, 208-215/共著/2006.11
主な担当授業科目名 薬理学Ⅱ、生物系実習Ⅱ、薬学総括講義Ⅰ、薬学総括講義Ⅲ、臨床薬学実習Ⅱ、卒業研究