水間 俊
Faculty

学部・大学院

水間 俊

所属 薬学部 薬学科 教授
最終学歴 東京薬科大学大学院薬学研究科博士課程
現在所属している学会 日本薬学会、日本薬物動態学会、日本薬剤学会、情報計算化学生物学会(CBI学会)、American Association of Pharmaceutical Scientists、日本DDS学会
学士・修士・博士 薬学士、薬学修士、薬学博士
所有資格 薬剤師免許
研究の分野 薬学
主な研究項目 薬物の腸管における吸収と代謝 eADMET、飲食物成分の体内動態と相互作用
主な研究業績 未解明の薬物動態におけるタンパク結合のインパクト/CBI学会誌7(4)、39−40/単著
Human serum albumin binding of 3, 5, 6, 7, 8, 3’, 4’-heptamethoxyflavone, a citrus flavonoid possessing a neuroprotective effect./Chem-Bio Informatics Journal, 17, 103-109/共著/2017.11
A Toxicity Risk Index, An Index for Warning Idiosyncratic Drug Toxicity/J. Pharm. Sci, 102, 3447-3450/共著/2013.09
Kinetic assessment of luminal degradation of orally effective prodrugs for rational drug development./J. Pharm. Sci. 99, 1078-1086/単著/2010.02
Intestinal glucuronidation metabolism may have a greater impact on oral bioavailability than hepatic glucuronidation metabolism in humans: a study with raloxifene, substrate for UGT1A1, 1A8, 1A9, and 1A10./Int. J. Pharm. 378, 140-141/単著/2009.08
Assessment of presystemic and systemic intestinal availability of orally administered drugs using in vitro and in vivo data in humans: Intestinal sulfation metabolism impacts presystemic availability much more than systemic availability of salbutamol, SULT1A3 substrate./J. Pharm. Sci. 97, 5471-5476/単著/2008.12
Photoinduced covalent binding of furosemide and furosemide glucuronide to human serum albumin./Br. J. Clin. Pharmacol., 48, 79-87/共著/1999.07
Factors that cause β-anomeric preference of Na+/glucose cotransporter for intestinal transport of monosaccharide conjugates./Biochim. Biophys. Acta., 1381, 340-346/共著/1998.08
The β-anomeric and glucose preferences of glucose transport carrier for intestinal active absorption of monosaccharide conjugates./Biochim. Biophys. Acta., 1200, 117-122/共著/1994.07
Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugs./Biochem. Pharmacol., 43, 2037-2039/共著/1992.05
Factors influencing drug sulfate and glucuronic acid conjugation rate in isolated rat hepatocytes: significance of preincubation time./Biochem. Pharmacol., 34, 2573-2575/共著/1985.07
Differentiation of organ availability by sequential analysis and simultaneous analysis: intestinal conjugative metabolism impacts on intestinal availability in humans/J. Pharm. Sci. 94, 571-575/共著
Uptake of cyclic dipeptide by PEPT1 in Caco-2 cells: phenolic hydroxyl group of substrate enhances affinity for PEPT1 J. Pharm. Pharmacol. 54, 1293-1296 (2002)/J. Pharm. Pharmacol. 54, 1293-1296/共著
Intestinal absorption and analgesic activity of cellobiose-coupled leucine enkephalinamide./Biopharm. Drug Dispos., 19, 605-610/共著
Intestinal absorption of stable cyclic dipeptides by oligopeptide transporter./J. Pharm. Pharmacol., 50, 167-172/共著
Intestinal Na+/glucose cotransporter-mediated transport of glucose conjugate formed from disaccharide conjugate. Biochim. Biophys. Acta., 1379, 1-6 (1998)./Biochim. Biophys. Acta., 1379, 1-6/共著
Intestinal absorption of lactonolactone-coupled tripeptide and stability in serum: effect of linkage between peptide and monosaccharide moiety./Protein and Peptide Letters, 4, 115-122/共著
Preference of Peyer’s Patches to jejunal epithelium for intestinal absorption of oligopeptides, tyrosylglycylglycine and D-kyotorphine./Biol. Pharm. Bull., 20, 1024-1025/共著
Improvement of intestinal absorption of leucine enkephalin by sugar coupling and peptidase inhibitors./J. Pharm. Sci., 85, 854-857/共著
Transport of low and high molecular peptides across rabbit Peyer’s patches./Pharm. Res. 11, 361-364/共著
Na+-dependent transport of aminopeptidase-resistant sugar-coupled tripeptides in rat intestine./Biochem. Biophys. Res. Commun., 203, 1412-1416/共著
Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible binding and irreversible binding./Biopharm. Drug Dispos., 20, 131-136/共著
Inhibition of the hepatic uptake of paracetamol sulphate by anionic compounds./J. Pharm. Pharmacol., 49, 743-746/共著
Species and organ differences of sulphate conjugation of p-nitrophenol in liver and platelets. Chem./Chem. Pharm. Bull., 40, 1964-1965/共著
Sulphate conjugation enhances reversible binding of drug to human serum albumin./J. Pharm. Pharmacol., 43, 446-448/共著
Correlation of phenol sulfotransferase activities in the liver and platelets of rat./J. Pharm. Pharmacol., 42, 207-208/共著
Aryl sulfotransferase in rat liver: multiplicity and substrate specificity./J. Pharmacobio-Dyn., 10, 736-742/共著
Characterization of the interaction of albumin with isolated rat liver cells to reveal the mechanism of albumin-mediated hepatic transport./J. Pharmacobio-Dyn., 9, 244-248/共著
Heterogenous distribution of the conjugation activity of acetaminophen and p-nitrophenol in isolated rat liver cells./J. Pharmacobio-Dyn., 9, 218-222 (/共著
The effect of albumin on the uptake of bromosulfophthalein by isolated rat hepatocytes./J. Pharmacobio-Dyn., 8, 90-94/共著
Heterogenous distribution of conjugation activities of harmol in isolated rat liver cells./J. Pharmacobio-Dyn., 7, 624-629/共著
p-Nirophenol sulfation in rat liver cytosol: multiple forms and substrate inhibition of aryl sulfotransferase. J. Pharmacobio-Dyn., 6, 851-858 (1983)./J. Pharmacobio-Dyn., 6, 851-858/共著
p-Nitrophenol sulfate conjugation with substrate inhibition in rat liver cytosol fraction./Chem. Pharm. Bull., 31, 4565-4567/共著
Correlation of drug conjugative metabolism rates between in vivo and in vitro: glucuronidation and sulfation of p-nitrophenol as a model compound in rat. J. Pharmacobio-Dyn. 5, 811-817 (1982)./J. Pharmacobio-Dyn. 5, 811-817/共著
Intestinal absorption of stable cyclic glycylphenylalanine: comparison with the linear form./J. Pharm. Pharmacol., 49, 1067-1071/共著
Cellulase-catalyzed transglucosylation of acetaminophen and acyclovir./Pharm. Res., 14, 1647-1650/共著
Transport mechanisms of a glycoside, p-nitrophenyl-β-D-glucopyranoside, across rat small intestinal brush-border membranes./Biochim. Biophys. Acta., 1370, 192-198/共著
Intestinal absorption and analgesic activity of cellobiose-coupled leucine enkephalinamide./Biopharm. Drug Dispos., 19, 605-610/共著
Intestinal absorption of acyclovir -glucoside: comparative study with acyclovir, guanosine and kinetin -glucoside./Pharm. Res., 16, 69-73/共著
Intestinal transport of -thioglycosides by Na+/glucose cotransporter./J. Pharm. Pharmacol., 52, 303-310/共著
Kinetic characterization of glycosidase activity from disaccharide conjugate to monosaccharide conjugate in Caco-2 cells./J Pharm Pharmacol. 57, 661-664/共著
Pharmacokinetic strategy for designing orally effective prodrugs overcoming biological membrane barriers: proposal of kinetic classification and criteria for membrane-permeable prodrug-likeness./Chem-Bio Informatics Journal, 8, 25-32 (2008)/単著
Integrated pharmacokinetic assessment and strategy for orally effective prodrugs overcoming luminal degradation and biological membrane barriers./Chem-Bio Informatics Journal 8, 58-68/単著
Dietary polyphenols (-)-epicatechin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption./J. Pharm. Sci. 93, 2407-2410/共著
Does the well-stirred model assess the intestinal first-pass effect well?/J Pharm Pharmacol. 56, 1597-1599/共著
Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosyl-glycylglycine by intestinal Na+/glucose cotransporter (SGLT1): Recognition of SGLT1 is much less restricted than transport./Biol. Pharm. Bull. 22, 876-879/共著
High performance liquid chromatographic identificaiton and determination of photodegaradation and acyl migration products of furosemide 1-O-acyl glucuronide./J. Chromatogr. B., 718, 153-162/共著
Predictability of the covalent binding of acidic drugs in man./Life Sci., 53, PL141-146/共著
Transport of acetaminophen conjugates in isolated rat hepatocytes./Dug Metab. Dispos., 17, 341-344/共著
Fluorescence energy transfer study of the relationship between the lone tryptophan residue and drug binding sites in human serum albumin./J. Pharm. Sci., 76, 387-392/共著
Comparative study of active absorption by the intestine and disposition of anomers of sugar conjugated compounds./Biochem. Pharmacol., 45, 1520-1523/共著
Predictive Performance of Vancomycin Trough Concentrations in Patients With Diabetes With Microalbuminuria./Ther Drug Monit. 39, 614-616/共著
Conformational change in plasma albumin due to interaction with isolated rat hepatocytes./Am. J. Physiol., 264, G456-470/共著
Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenol, acetaminophen and 1-naphthol: kinetic demonstration of the influence of glucuronidation metabolism on intestinal absorption in rats./Biochim. Biophys. Acta.,1425, 398-404/共著
難吸収性薬物の吸収性改善と新規投与製剤の開発/シーエムシー/共著/2012.04
遺伝子医学MOOK 別冊 ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用/メディカルドゥ/共著/2011.06
創薬研究のストラテジー/日本薬理学会編 金芳堂/共著/2011.03
主な担当授業科目名 生物薬剤学、薬物動態解析、薬剤学特論、薬学総括講義II、臨床薬学実習II、卒業研究