水間 俊
Faculty

学部・大学院

水間 俊

所属 薬学部 薬学科 教授
最終学歴 東京薬科大学大学院薬学専攻博士課程
現在所属している学会 日本薬学会、日本薬物動態学会、日本薬剤学会、情報計算化学生物学会(CBI学会)、American Association of Pharmaceutical Scientists、日本DDS学会
学士・修士・博士 薬学博士、薬学修士、薬学士
所有資格 薬剤師免許
研究の分野 薬物動態学
主な研究項目 薬物の腸管における吸収と代謝 eADMET
主な研究業績 Human serum albumin binding of 3, 5, 6, 7, 8, 3’, 4’-heptamethoxyflavone, a citrus flavonoid possessing a neuroprotective effect./Chem-Bio Informatics Journal, 17, 103-109/共著/2017.11
A Toxicity Risk Index, An Index for Warning Idiosyncratic Drug Toxicity/J. Pharm. Sci, 102, 3447-3450/共著/2013.09
Kinetic assessment of luminal degradation of orally effective prodrugs for rational drug development./J. Pharm. Sci. 99, 1078-1086/単著/2010.02
Intestinal glucuronidation metabolism may have a greater impact on oral bioavailability than hepatic glucuronidation metabolism in humans: a study with raloxifene, substrate for UGT1A1, 1A8, 1A9, and 1A10./Int. J. Pharm. 378, 140-141/単著/2009.08
Assessment of presystemic and systemic intestinal availability of orally administered drugs using in vitro and in vivo data in humans: Intestinal sulfation metabolism impacts presystemic availability much more than systemic availability of salbutamol, SULT1A3 substrate./J. Pharm. Sci. 97, 5471-5476/単著/2008.12
Photoinduced covalent binding of furosemide and furosemide glucuronide to human serum albumin./Br. J. Clin. Pharmacol., 48, 79-87/共著/1999.07
Factors that cause β-anomeric preference of Na+/glucose cotransporter for intestinal transport of monosaccharide conjugates./Biochim. Biophys. Acta., 1381, 340-346/共著/1998.08
The β-anomeric and glucose preferences of glucose transport carrier for intestinal active absorption of monosaccharide conjugates./Biochim. Biophys. Acta., 1200, 117-122/共著/1994.07
Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugs./Biochem. Pharmacol., 43, 2037-2039/共著/1992.05
Factors influencing drug sulfate and glucuronic acid conjugation rate in isolated rat hepatocytes: significance of preincubation time./Biochem. Pharmacol., 34, 2573-2575/共著/1985.07
難吸収性薬物の吸収性改善と新規投与製剤の開発/シーエムシー/共著/2012.04
遺伝子医学MOOK 別冊 ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用/メディカルドゥ/共著/2011.06
創薬研究のストラテジー/日本薬理学会編 金芳堂/共著/2011.03
主な担当授業科目名 生物薬剤学、薬物動態解析、薬剤学特論、薬学総括講義II、臨床薬学実習II、卒業研究