高松 智
Faculty

学部・大学院

高松 智

所属 薬学部 薬学科 教授
最終学歴 千葉大学大学院薬学研究科博士後期課程
現在所属している学会 日本薬学会、日本生薬学会、米国生薬学会、SHR等疾患モデル共同研究会、和漢医薬学会
学士・修士・博士 薬学博士
所有資格 薬剤師
研究の分野 薬学, 応用微生物学
主な研究項目 微生物由来の生物活性物質の探索、健康寿命延伸に向けた漢方薬の評価、天然由来の抗酸化物質の探索
主な研究業績 抗老化を目指した天然資源の探索研究/アグリバイオ、第1巻 12月号 No.13、p.70-76/共著/2018.12
Naturally occurring cell adhesion inhibitors 査読付/Journal of Natural Medicines 72巻4号、pp.817-835/単著/2018.04
抗老化を目指した生薬及び漢方薬の評価/月刊細 胞(10月臨時増刊号)、第49巻 10月号 No.12、p.44~48/共著/2017.10
生薬・薬用植物研究が明らかにする漢方の実力/月刊ファインケミカル  シーエムシー出版/共著/2017.06
微生物由来の細胞接着阻害剤Macrosphelide 査読付/昭和大学薬学雑誌 4巻1号、pp.37-46/単著/2013.01
Effect of intraoral antioxidative capacity in orengedokuto/Traditional and Kampo Medicine, 7巻 1号, pp.30-37/共著/2020.01
Antibacterial activity of Hepericum erectum (査読付き)/The Showa University Journal of Medical Sciences, 26巻4号 pp.283-291/共著/2014.04
Effects of the herbal medicine composition 'Saiko-ka-ryukotsu-borei-To' on the function of endothelial progenitor cells in hypertensive rats (査読付き)/Phytomedicine, 20巻3-4号 pp.196-201/共著/2013.04
Total synthesis and absolute configuration of avenolide, extracellular factor in Streptomyces avermitilis(査読付き)/J. Antibiotics, 64巻12号 pp.781-787/共著/2011.12
Inhibitory Effects of Constituents from Morus alba var. multicaulis on Differentiation of 3T3-L1 Cells and Nitric Oxide Production in RAW264.7 Cells(査読付き)/Molecules, 16巻7号 pp.6010-6022/共著/2011.07
Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis (査読付き)/Proc. Natl. Acad. Sci. USA, 108巻, no.39号 pp.166410-16415/共著/2011.05
Characterization of a silent sesquiterpenoid biosynthetic pathway in Streptomyces avermitilis controlling epi-isozizaene albaflavenone biosynthesis and isolation of a new oxidized epi-isozizaene metabolite(査読付き)/Microbial Biotechnology, 4巻2号 pp.184-191/共著/2011.02
Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis(査読付き)/J. Antibiotics, 64巻1号 pp.65-71/共著/2011.01
Regio- and stereo-specificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis (査読付き)/J. Biol. Chem., 285巻22号 pp.16844-16853/共著/2010.09
Nocardamin Production by Streptomyces avermitilis (査読付き)/Actinomycetologica, 23巻2号 pp.34-39/共著/2009.02
Genome Mining in Streptomyces avermitilis. A Biochemical Baeyer-Villiger Reaction and Discovery of a New Branch of the Pentalenolactone Family Tree(査読付き)/Biochemistry, 48巻27号 pp.6431-6440/共著/2009.02
Constituents of Zanthoxylum flavum and their Antioxidant and Antimalarial Activities(査読付き)/Natural Product Communications, 3巻5号 pp.791-794/共著/2008.05
COX-2 Inhibitory Activity of Cafestol and Analogs from Coffee Beans(査読付き)/Natural Product Communications, 3巻1号 pp.11-16/共著/2008.01
Screening for free radical scavenging and cell aggregation inhibitory activities by secondary metabolites from Turkish Verbascum species(査読付き)/Z. Naturforsch. [C],62巻9-10号 pp.673-678/共著/2007.10
A Gene Cluster for Biosynthesis of the Sesquiterpenoid Antibiotic Pentalenolactone in Streptomyces avermitilis (査読付き)/Biochemistry, 45巻19号 pp.6179-6186/共著/2006.06
Schisandrene, a Dibenzocyclooctadiene Lignan from Schisandra chinensis: Structure-Antioxidant Activity Relationships of Dibenzocyclooctadiene Lignans (査読付き)/J. Nat. Prod, 69巻3号 pp.356-359/共著/2006.03
Isolation of lignans and biological activity studies of Ephedra viridis (査読付き)/Planta Medica, 71巻8号 pp.787-789/共著/2005.08
Antioxidant lignans from Larrea tridentata (査読付き)/Phytochemistry, 65巻17号 pp. 2499-2505/共著/2004.09
A New Antimalarial Quassinoid from Simaba orinocensis(査読付き)/J. Nat. Prod, 67巻5号 pp.772-777/共著/2004.05
Secondary Metabolites from Marine Cyanobacteria and Algae Inhibit LFA-1/ICAM-1 Mediated Cell Adhesion(査読付き)/Planta Medica, 70巻2号 pp.127-131/共著/2004.02
Cytotoxic and antioxidant activity of alkylated benzoquinones from Maesa lanceolata(査読付き)/Phytotherapy Research, 17巻8号 pp.887-891/共著/2003.08
New cell-cell adhesion inhibitors from Streptomyces sp. UMA-044(査読付)/J. Antibiotics, 56巻8号 pp.673-681/共著/2003.08
Antioxidant Effect of Flavonoids on Intracellular ROS in HL-60 Cells(査読付き)/Phytotherapy Research, 17巻8号 pp.963-966/共著/2003.08
Antiparasitic Alkaloids from Psychotria klugii (査読付き)/J. Nat. Prod, 66巻5号 pp.962-967/共著/2003.05
Marine Natural Products as Novel Antioxidant Prototypes(査読付き)/J. Nat. Prod, 66巻5号 pp.605-608/共著/2003.05
Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1(査読付き)/Immunity, 19巻2号 pp.243-255/共著/2003.02
Cytotoxic Sesquiterpene Lactons from Centaurothamnus mximus and Vicoa pentanema(査読付き)/Phytotherapy Research, 17巻2号 pp.168-173/共著/2003.02
Biologically Active Secondary Metabolites from Ginkgo biloba(査読付き)/J. Agric. Food Chem., 50巻11号 pp.3150-3155/共著/2002.11
Characterization of Mycotypha metabolites found to be inhibitors of cell adhesion molecules(査読付き)/J. Antibiotics, 55巻6号 pp.585-592/共著/2002.06
A New Dehydrogeranyl-geraniol Antioxidant from Saururus cernuus L. that Inhibits Intracellular Reactive Oxygen Species (ROS)-Catalyzed Oxidation within HL-60 Cells(査読付き)/J. Nat. Prod, 64巻6号 pp.693-695/共著/2001.06
Madindoline, a novel inhibitor of IL-6 activity from Streptomyces sp. K93-0711. II. Physico chemical properties and structural elucidation(査読付き)/J. Antibiotics, 50巻12号 pp.1069-1072/共著/1997.12
Macrosphelide C and D, novel inhibitor of cell adhesion(査読付き)/J. Antibiotics, 50巻10号 pp.878-880/共著/1997.10
Amphistin, new melanin synshesis inhibitor produced by Streptomyces sp. KP-3052(査読付き)/J. Antibiotics, 50巻10号 pp.808-814/共著/1997.10
The relative and stereochemisties and total synthesis of (+)-macrosphelides A and B, potent orally bioavailable inhibitors of cell-cell adhesion molecule(査読付き)/J. Am. Chem. Soc., 119巻42号 pp.10247-1024/共著/1997.08
Efficient chemical conversion of louisianin A to C and D, the inhibitor of angiogenesis(査読付き)/J. Antibiotics, 50巻3号 pp.274-275/共著/1997.03
Pyridindolols K1 and K2, new alkaloids from Streptomyces sp. K93-0711 (査読付き)/J. Antibiotics, 50巻3号 pp.189-193/共著/1997.03
Madindoline, a novel inhibitor of IL-6 activity from Streptomyces sp. K93-0711. I. Taxonomy, fermentation, isolation and biological activities (査読付き)/J. Antibiotics, 49巻11号 pp.1091-1095/共著/1996.11
Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. I.Taxonomy, fermentation, isolation and biological activitie (査読付き)/J. Antibiotics, 49巻7号 pp.631-634/共著/1996.07
Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. I.Taxonomy, fermentation, isolation and biological activitie (査読付き)/J. Antibiotics, 49巻7号 pp.631-634/共著/1996.07
A new inhibitor of melanogenesis, albocycline K3 produced by Streptomyces sp. OH-3984 (査読付き)/J. Antibiotics, 49巻5号 pp.485-486/共著/1996.05
Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. II. Physico-chemical properties and structural elucidation(査読付き)/J. Antibiotics, 49巻1号 pp.95-98/共著/1996.01
Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. I.Taxonomy, fermentation, isolation and biological activities (査読付き)/J. Antibiotics, 48巻12号 pp.1435-1439/共著/1995.12
Louisianins A, B, C and D: Non-steroidal growth inhibitor of testosterone responsive SC-115 cells. II. Physico-chemical properties and structural elucidation(査読付き)/J. Antibiotics, 48巻10号 pp.1090-1094/共著/1995.10
Louisianins A, B, C and D: Non-steroidal growth inhibitor of testosterone responsive SC-115 cells. I. Taxonomy, fermentation, isolation and biological characteristics (査読付き)/J. Antibiotics, 48巻10号 pp.1086-1089/共著/1995.10
Relative and absolute stereochemistry of the melanogenesis inhibitors, OH-3984 K1 and K2. Partial synthesis from albocycline (査読付き)/Tetrahedron Letters, 35巻17号 pp.2635-2636/共著/1994.07
A novel testosterone 5α-reductase inhibitor, 8',9'-dehydroascochlorin produced by Verticillium sp. FO-2787(査読付き)/Chem. Pharm. Bull., 42巻4号 pp.953-956/共著/1994.04
A glycosidic lupin alkaloid from Lupinus hirsutus(査読付き)/Phytochemistry, 37巻2号 pp.591-592/共著/1994.02
New inhibitors of melanogenesis, OH-3984 K1 and K2: II. Physico-chemical properties and structural elucidation(査読付き)/J. Antibiotics, 46巻10号 pp.1526-1529/共著/1993.10
New inhibitors of melanogenesis, OH-3984 K1 and K2: I. Taxonomy, fermentation, isolation and biological characteristics(査読付き)/J. Antibiotics, 46巻10号 pp.1520-1525/共著/1993.10
Acyltransferases for lupin alkaloids in Lupinus hirsutus(査読付き)/Phytochemistry 32巻1号 pp.87-91/共著/1993.01
Lupin alkaloids from Sophora exigua(査読付き)/Phytochemistry, 30巻11号 pp.3793-3795/1991.11
Stereostructure of (-)-multiflorine N-oxide: A new lupin alkaloid from Lupinus hirsutus(査読付き)/Heterocycles, 32巻6号 pp.1167-1171/共著/1991.02
New lupine alkaloids from the seedlings of Lupinus hirsutus and change of alkaloid pattern with germination(査読付き)/J. Nat. Prod, 54巻2号 pp.477-482/共著/1991.02
Glycosidic lupin alkaloids from Lupinus hirsutus(査読付き)/Phytochemistry, 29巻12号 pp.3923-3926/共著/1990.12
Lupin alkaloids in tissue culture of Sophora flavescens var. angustifolia: Greening induced production of matrine(査読付き)/Chem. Pharm. Bull., 37巻11号 pp.3001-3004/共著/1989.11
Greening induced production of (+)-lupanine in tissue culture of Thermopsis lupinoides(査読付き)/Phytochemistry, 28巻9号 pp.2341-2344/共著/1989.09
Isolation of a new alkaloid (-)-O-acetylbaptifoline and the absolute stereochemical relationships of lupin alkaloids in Thermopsis chinensis(査読付き)/J. Nat. Prod, 52巻5号 pp.1032-1035/共著/1989.05
Isolation of a new alkaloid (-)-O-acetylbaptifoline and the absolute stereochemical relationships of lupin alkaloids in Thermopsis chinensis(査読付き)/J. Nat. Prod, 52巻5号 pp.1032-1035/共著/1989.05
Absolute configuration of (+)-5,6-dehydrolupanine, a key intermediate in biosynthesis of lupin alkaloids(査読付き)/Phytochemistry, 28巻3号 pp.958-959/共著/1989.03
Lupin alkaloids from the seeds of Thermopsis lupinoides(査読付き)/Phytochemistry, 27巻11号 pp.3715-371/共著/1988.11
生薬・薬用植物研究の  最新動向/シーエムシー出版/共著/2017.08
漢方294処方生薬解説 -その基礎から運用まで-/万来舎/共著/2016.09
主な担当授業科目名 薬学入門、薬用植物学