斧 康雄
Faculty

学部・大学院

斧 康雄

所属 健康メディカル学部 医療科学科 教授
 副学長
健康メディカル学部 学部長
健康メディカル学部 医療科学科 学科長
健康科学研究科 病院前救急医療学専攻 専攻長
最終学歴 徳島大学医学部 医学科
現在所属している学会 日本感染症学会、日本内科学会、日本消化器病学会、日本化学療法学会、日本環境感染学会、日本救急医学会、プライマリケア学会、日本臨床微生物学会、日本細菌学会、日本臨床検査学会、日本呼吸器病学会、米国微生物学会(ASM)、欧州臨床微生物・感染症学会(ESCMID)
学士・修士・博士 医学士(徳島大学)、医学博士(東京大学)
所有資格 総合内科専門医、感染症専門医/指導医、消化器病専門医、インフェクションコントロールドクター(ICD)、抗菌化学療法指導医/抗菌薬臨床試験指導医、医師免許、日本医師会認定健康スポーツ医、日本医師会認定産業医
研究の分野 内科系臨床医学、基礎医学、薬学
主な研究項目 好中球を中心とした感染防御機構の解析、薬剤耐性菌の病原性と耐性機構の解析、易感染宿主や敗血症を中心とした重症感染症の病態解析と治療に関する研究、感染予防対策、抗菌化学療法
主な研究業績 標準微生物学第14版.レンサ球菌属,腸球菌属, P136-144/医学書院/共著/2021.03
臨床検査ガイド2020年改訂版.細菌性感染症を疑った場合の検査の進め方,検査データの評価をする際のポイント.P4ー13/文光堂/共著/2020.06
シンプル内科学 改訂第2版.第7章 感染症.P99-146,/南江堂/共著/2017.10
感染症専門医テキスト改訂第2版,第I部解説編/南江堂/共著/2017.03
高齢者感染症.超高齢社会の課題と特徴.総論II 高齢者の易感染性,加齢による食細胞機能の変動/医薬ジャーナル社/共著/2016.06
医療関連感染対策なるほどABC. 改訂2版/ヴァンメディカル社/単著/2013.03
感染症クリニカルガイダンス/ヴァンメディカル社/共著/2005.03
活性酸素の病気へのかかわり/全国病院出版会/単著/1999.01
Acinetobacter baumannii LOS Regulate the Expression of Inflammatory Cytokine Genes and Proteins in Human Mast Cells. Pathogens. 2021 Mar 3;10(3):290./共著/2021.03
Development of a rapid scabies immunodiagnostic assay based on transcriptomic analysis of Sarcoptes scabiei var. nyctereutis. Sci Rep. 2021 Mar 19;11(1):6455./共著/2021.03
Immunomodulatory gene expression analysis in LPS-stimulated human polymorphonuclear leukocytes treated with antibiotics commonly used for multidrug-resistant strains. Mol Immunol. 2021 Jan;129:39-44./共著/2021.01
Analysis of Immune Responses in Acinetobacter baumannii-Infected Klotho Knockout Mice: A Mouse Model of Acinetobacter baumannii Infection in Aged Hosts. Front Immunol. 2020 Nov 23;11:601614/共著/2020.11
Emergence of Enterobacter cloacae Complex Co-Producing IMP-10 and CTX-M, and Klebsiella pneumoniae Producing VIM-1 in Clinical Isolates in Japan. Microorganisms. 2020 Nov 18;8(11):1816. doi: 10.3390/microorganisms8111816./共著/2020.11
Lipopolysaccharide-Deficient Acinetobacter Baumannii Due to Colistin Resistance Is Killed by Neutrophil-Produced Lysozyme. Front Microbiol. 2020 Apr 17;11:573./共著/2020.04
Genomic analysis of a pan-resistant Klebsiella pneumoniae sequence type 11 identified in Japan in 2016. Int J Antimicrob Agents. 2020 Apr;55(4):105854./共著/2020.04
A Novel Mismatched PCR-Restriction Fragment Length Polymorphism Assay for Rapid Detection of gyrA and parC Mutations Associated With Fluoroquinolone Resistance in Acinetobacter baumannii. Ann Lab Med. 2020 Jan;40(1):27-32./共著/2020.01
The complete mitochondrial genome of Sarcoptes scabiei var. nyctereutis from the Japanese raccoon dog: Prediction and detection of two transfer RNAs (tRNA-A and tRNA-Y). Genomics. 2019 Dec;111(6):1183-1191./共著/2019.12
Multidrug-resistant Acinetobacter baumannii resists reactive oxygen species and survives in macrophages. Sci Rep. 2019 Nov 25;9(1):17462. doi: 10.1038/s41598-019-53846-3./共著/2019.11
Prevalence and mechanism of fluoroquinolone resistance in clinical isolates of Proteus mirabilis in Japan. Heliyon. 2019 Mar 2;5(3):e01291./共著/2019.03
Comparative analysis of the pathogenicity between multidrug-resistant Acinetobacter baumannii clinical isolates: isolation of highly pathogenic multidrug-resistant A. baumannii and experimental therapeutics with fourth-generation cephalosporin cefozopran. Infect Drug Resist. 2018 Oct 10;11:1715-17/共著/2018.10
Emergence of multiple carbapenemase-producing Gram-negative species, colistin-resistant KPC-2-producing Klebsiella pneumoniae ST11, IMP-7-producing Pseudomonas aeruginosa ST357, and OXA-23-producing Acinetobacter baumannii ST1050, in a single patient. Int J Antimicrob Agents. 2018 Oct;52(4):512-514./共著/2018.10
Resolvin E1, but not Resolvins E2 and E3, promotes fMLF-induced ROS generation in human neutrophils. FEBS Lett. 592(16):2706-2715, 2018 Palmitoyl lactic acid induces adipogenesis and a brown fat-like phenotype in 3T3-L1 preadipocytes. Biochim. Biophys.Acta. 1863(7):772–782, 2018/共著/2018.08
Palmitoyl lactic acid induces adipogenesis and a brown fat-like phenotype in 3T3-L1 preadipocytes. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul;1863(7):772-782./共著/2018.04
Sub-minimum inhibitory concentrations of colistin and polymyxin B promote Acinetobacter baumannii biofilm formation. PLoS One. 2018 Mar 19;13(3):e0194556./共著/2018.03
Pathogenic Bacterium Acinetobacter baumannii Inhibits the Formation of Neutrophil Extracellular Traps by Suppressing Neutrophil Adhesion. Front Immunol. 2018 Feb 7;9:178./共著/2018.02
Improving the quality of a recombinant rabbit monoclonal antibody against PLXDC2 by optimizing transient expression conditions and purification method. Protein Expr Purif. 2018 Jun;146:27-33./共著/2018.01
The TNF-α of mast cells induces pro- inflammatory responses during infection with Acinetobacter baumannii. Immunobiology. 2017 Nov;222(11):1025-1034./共著/2017.11
Acinetobacter baumannii Lipopolysaccharide Influences Adipokine Expression in 3T3-L1 Adipocytes. Mediators Inflamm. 2017;2017:9039302./共著/2017.07
Spontaneous formation of neutrophil extracellular traps in serum-free culture conditions. FEBS Open Bio. 2017 May 2;7(6):877-886./共著/2017.05
Lactobacillus Paraplantarum 11-1 Isolated from Rice Bran Pickles Activated Innate Immunity and Improved Survival in a Silkworm Bacterial Infection Model. Front Microbiol. 2017 Mar 20;8:436./共著/2017.03
New techniques to collect live Sarcoptes scabiei and evaluation of methods as alternative diagnostics for infection. Parasitol Res. 2017 Mar;116(3):1039-1042./共著/2017.03
Inhibition of Neutrophil Adhesion and Antimicrobial Activity by Diluted Hydrosol Prepared from Rosa damascena. Biol Pharm Bull. 2017;40(2):161-168./共著/2017.02
Virulence characteristics of Acinetobacter baumannii clinical isolates vary with the expression levels of omps. J Med Microbiol. 2017 Feb;66(2):203-212./共著/2017.02
A novel bacterial transport mechanism of Acinetobacter baumannii via activated human neutrophils through interleukin-8. J Leukoc Biol. 2016 Dec;100(6):1405-1412./共著/2016.12
Improving the soluble expression and purification of recombinant human stem cell factor (SCF) in endotoxin-free Escherichia coli by disulfide shuffling with persulfide. Protein Expr Purif. 2016 Apr;120:99-105./共著/2016.04
Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm. Drug Discov Ther. 2016 Feb;10(1):49-56./共著/2016.02
Loop-mediated isothermal amplification: Rapid and sensitive detection of the antibiotic resistance gene ISAba1-blaOXA-51-like in Acinetobacter baumannii. J Microbiol Methods. 2016 Feb;121:36-40./共著/2016.02
主な担当授業科目名 救急医学概論II・Ⅲ、疾病救急II・Ⅲ、免疫学(臨工)