金子 希代子
Faculty

学部・大学院

金子 希代子

所属 薬学部 薬学科 教授
最終学歴 東京大学大学院薬学系研究科生命薬学専攻修士課程修了
現在所属している学会 日本痛風•尿酸核酸学会、日本薬学会、日本尿路結石症学会、日本生化学会、日本臨床栄養学会、日本リウマチ学会
学士・修士・博士 東京大学薬学博士
所有資格 教員、薬剤師、第1種放射線取扱主任者
研究の分野 6802,7207,7307
主な研究項目 プリン代謝、機器分析
主な研究業績 Determination of total purine and free purine content in milk, soymilk, and enteral nutritional supplements to assist nutritional therapy for hyperuricemia and gout./The 19th Symposium on Purine and Pyrimidine Metabolism in Man (PP21), 2021年6月14-16日、オンライン開催/共著/2021.06
Purine content of hospital meals and its effect on serum uric acid, urine pH, and urinary uric acid excretion./The 19th Symposium on Purine and Pyrimidine Metabolism in Man (PP21), 2021年6月14-16日、オンライン開催/共著/2021.06
講演 食事性酸負荷(PRAL)と尿路結石症、高尿酸血症を含む生活習慣病との関連/日本尿路結石症学会第30回学術集会 ランチョンセミナー。オンライン開催。2021年1月27日/共著/2021.01
総説 特集/アルコールによる代謝異常と疾患。『アルコールと核酸代謝異常』/糖尿病・内分泌代謝科 52 (1): 1-8, 2021. 1月/共著/2021.01
総説 特集/心血管疾患の残余リスクとしてのキサンチンオキシダーゼ(XO)『血清尿酸値を上昇させる食生活』/循環器内科 87 (1): 95-101/共著/2020.01
講演 『知っておきたいプリン体の話 〜腎臓を守り、健康を保つために〜』/亀岡市医師会市民公開講座/単著/2019.11
講演 シンポジウム「子育て世代と共生する―すべての人が働きやすい 環境づくりのために―」/第53回 日本実験動物技術者協会総会 in 松山/共著/2019.10
講演 『尿酸と尿路結石〜再発予防に向けて〜。』/第30回 痛風・尿酸研修会/単著/2019.09
講演 国際学会シンポジウム“Women in Science”/The 6th International Symposium on Bioimaging & The 28th Annual Meeting of the Bioimaging Society/共著/2019.09
総説 特集 高尿酸血症と痛風における生活指導の最前線 —「高尿酸血症・痛風の治療ガイドライン第3版」より/臨床栄養 135 (2): 177-183/共著/2019.09
総説 プリン体の測定と食事療法への応用/痛風と尿酸・核酸 43 (1): 1-9/共著/2019.07
WEB講義『痛風・高尿酸血症(ガイドライン第3版に準じて)』/医療教育研究所にで収録/単著/2019.06
会長講演 『プリン代謝研究と尿路結石の微細分析』/第52回 日本痛風・核酸代謝学会(帝京大学板橋キャンパスにて)/単著/2019.02
総説 「巻頭グラビア」目でみる 食事療法シリーズ/高尿酸血症と痛風 21(2): 109-112〜 25(1):1-6/共著/2017.03
Effects of islatravir (4'-ethynyl-2-fluoro-2'-deoxyadenosine or EFdA) on renal tubular cells and islatravir's interactions with organic anion transporters./J Pharmacol Sci. 2021 Jun;146(2):82-87. doi: 10.1016/j.jphs.2021.03.004./共著/2021.06
Differentiation of Positional Isomers of Halogenated Benzoylindole Synthetic Cannabinoid Derivatives in Serum by Hybrid Quadrupole/Orbitrap Mass Spectrometry./Anal Sci. 10;37 (2): 329-335. doi: 10.2116/analsci.20P252/共著/2021.02
Total Purine Content and Free Nucleosides, Nucleotides and Purine Bases Composition in Japanese Anchovies (Engraulis Japonicas) Using Highperformance Liquid Chromatography/Nucleosides Nucleotides Nucleic Acids. 39 (10-12), 1458-1464/共著/2020.04
Determination of Total Purine and Purine Base Content of 80 Food products to Aid Nutritional Therapy for Gout and Hyperuricemia./Nucleosides Nucleotides Nucleic Acids.doi: 10.1080/15257770.2020.1748197/共著/2020.04
Trial Analysis of Drug Profiling by Liquid Chromatography/Mass Spectrometry and Inductively Coupled Plasma Mass Spectrometry to Establish the Origin of Ephedrines Used as Precursors for Illicit Production of Methamphetamine./Rapid Commun Mass Spectrom, 33 (11), 995-1005/共著/2019.06
Determination of Dipicolinic Acid in "Natto" by High- Performance Liquid Chromatography Coupled With Postcolumn Photoirradiation With Zinc Acetate./Int J Tryptophan Res.doi: 10.1177/1178646919852120./共著/2019.06
Proteomic analysis of a urinary stone with two layers composed of calcium oxalate monohydrate and uric acid./Nucleosides Nucleotides Nucleic Acids.2018;37(12):717-723/共著/2018.07
In vitro enhancement of ATP in human erythrocytes from a healthy subject and two patients with thalassemia and hemoglobinopathy./Gout and Nucleic Acid Metabolism 42 (1): 59-64/共著/2018.05
The observed variation in the purine composition of food after soaking in sake lees./Nucleosides Nucleotides Nucleic Acids. 2018;37(6):348-352/共著/2018.05
Simultaneous quantification by HPLC of purines in umami soup stock and evaluation of their effects on extracellular and intracellular purine metabolism./Nucleosides Nucleotides Nucleic Acids. 2018;37(5):273-279./共著/2018.05
Clinical studies on changes in purine compounds in blood and urine by the simultaneous administration of febuxostat and inosine, or by single administration of each./Gout and Nucleic Acid Metabolism 141 (2): 171-181/共著/2017.05
Evaluation of cellular purine transport and metabolism in the Caco-2 cell using comprehensive high-performance liquid chromatography method for analysis of purines./Nucleosides, Nucleotides and Nucleic Acids 35(10-12): 663-669/共著/2016.12
Urinary excretion of uric acid, allantoin, and 8-OH-deoxyguanosine in uricase-knockout mice./Nucleosides, Nucleotides and Nucleic Acids 35(10-12): 559-565/共著/2016.12
Analysis of l-DOPA-derived melanin and a novel degradation product formed under alkaline conditions./Journal of Pharmaceutical and Biomedical Analysis. 125: 22-26/共著/2016.03
Targeting uric acid and the inhibition of progression to end-stage renal disease -A propensity score analysis./PLoS One. 10(12):e0145506. doi: 10.1371/journal.pone.0145506/共著/2015.12
Proteomic Analysis after Sequential Extraction of Matrix Proteins in Urinary Stones Composed of Calcium Oxalate Monohydrate and Calcium Oxalate Dihydrate./Ana Sci 31(9): 935-942/共著/2015.09
Analysis of Intra- and Extracellular Levels of Purine Bases, Nucleosides, and Nucleotides in HepG2 cells by High-performance Liquid Chromatography./Anal Sci 31(9): 895-901/共著/2015.09
Proteomic analysis to examine the role of matrix proteins in a gouty tophus from a patient with recurrent gout./Nucleosides, Nucleotides and Nucleic Acids, 33: 199-207/共著/2014.12
Proteomic analysis of a rare urinary stone composed of calcium carbonate and calcium oxalate dihydrate: A case report./Int J Urol, 21: 341-346/共著/2014.05
Total purine and purine base content of common foodstuffs for facilitating nutritional therapy for gout and hyperiricemia./Biological and Pharmaceutical Bulletin 37 (5): 709-721/共著/2014.05
Metabolic Interactions of Purine Derivatives with Human ABC Transporter ABCG2: Genetic Testing to Assess Gout Risk.(/Pharmaceuticals 2013, 6, 1347-1360, doi:10.3390/ph6111347/共著/2013.05
Comparison of matrix proteins in different types of urinary stone by proteomic analysis using liquid chromatography–tandem mass spectrometry./Int J Urol., 19(8), 765-772/共著/2012.08
Sensitive Analysis of Sialic Acid and Related Compound by Hydrophilic Interaction Liquid Chromatography Using Fluorescence Detection after Derivatization with DBD-PZ./Anal. Sci. 34: 841-844/共著
七訂 食品成分表2020資料編/女子栄養大学出版部/共著/2020.02
すべての診療科で役立つ栄養学と食事・栄養療法/羊土社/共著/2019.01
高尿酸血症・痛風の治療ガイドライン第3版/診断と治療社/共著/2018.12
代謝センシング/シーエムシー出版/共著/2018.09
薬学テキストシリーズ 分析化学II/朝倉書店/共著/2018.03
スマート栄養管理術123/医歯薬出版株式会社/共著/2014.01
尿路結石症のすべて/医学書院/共著/2008.08
健康とくすりシリーズ『痛風予防のABC』/薬事日報社/単著/2008.07
主な担当授業科目名 物理化学、臨床検査学